{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:41:30Z","timestamp":1781851290959,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The management of canine pemphigus foliaceus (PF) often requires long\u2010term immunosuppressive treatment that is often associated with unacceptable adverse effects. High\u2010dose glucocorticoid pulse therapy, an alternative protocole used for pemphigus in people, has been shown to provide rapid improvement in dogs with pemphigus foliaceus and vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To further identify the benefit of pulse therapy for management of canine PF, we compared the outcomes of oral glucocorticoid pulse and traditional therapies during the first 3\u00a0months of disease management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Dogs were allocated based on their oral glucocorticoid regimen during the first 12\u00a0weeks of PF management into the \u2018traditional\u2019 (20 dogs) or the \u2018pulse\u2019 (18 dogs) treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of dogs achieving complete remission (CR) during the first 12\u00a0weeks of treatment was significantly higher for the \u2018pulse\u2019 (61%) than for the \u2018traditional\u2019 group (15%;<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0063). The maximal oral glucocorticoid dosage given to dogs from the \u2018traditional\u2019 group was significantly higher (median: 3.2\u00a0mg\/kg) than that given between pulses to dogs from the other group (median: 1.1\u00a0mg\/kg;<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). There was no significant difference between groups in the time needed to achieve CR, the proportion of dogs requiring adjuvant immunosuppressive treatment or in the proportion of dogs experiencing severe adverse drug reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>These results suggest several benefits associated with oral glucocorticoid pulse therapy, such as a higher proportion of dogs achieving CR during the first 3\u00a0months, a lower average maximal oral glucocorticoid dosage given between pulses and minimal adverse drug events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12241","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T19:19:58Z","timestamp":1438888798000},"page":"354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Oral glucocorticoid pulse therapy for induction of treatment of canine pemphigus foliaceus \u2013 a comparative study"],"prefix":"10.1111","volume":"26","author":[{"given":"Petra","family":"Bizikova","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research NC State University Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Olivry","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research NC State University Raleigh NC 27606 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in five dogs with autoimmune skin disease","volume":"191","author":"White SD","year":"1987","journal-title":"J Am Vet Med Assoc"},{"issue":"1","key":"e_1_2_6_13_1","first-page":"87","article-title":"Randomized, controlled trial of methylprednisolone sodium succinate pulse therapy in canine pemphigus foliaceus: pilot study of 20 dogs","volume":"23","author":"Bensignor E","year":"2012","journal-title":"Vet Dermatol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.6.900"},{"key":"e_1_2_6_15_1","first-page":"242","article-title":"Comparison of three pulse methylprednisolone regimens in the treatment of rheumatoid arthritis","volume":"15","author":"Radia M","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009749209099236"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0022-3565(25)32295-0","article-title":"Prednisolone clearance at steady state in 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