{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:37:23Z","timestamp":1788568643337,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Canine sterile nodular panniculitis (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) is an inflammatory disease of the panniculus that is typically managed with immunomodulatory or immunosuppressive treatments. It has been reported to be a cutaneous marker of an underlying systemic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To assess the presence or absence of concurrent systemic diseases associated with canine<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>and to document breed predispositions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirty nine dogs presented to a veterinary teaching hospital from 1990 to 2012 which met inclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion in this retrospective study required a diagnosis of<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>via histopathological analysis and negative special stains for infectious organisms. Breed distributions of affected dogs were compared to all other dogs examined at this hospital during the study period. Correlations between the histological pattern of panniculitis and the histological presence of dermatitis, clinical presentation of lesions, dog breed and therapeutic outcomes were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Australian shepherd dogs, Brittany spaniels, Dalmatians, Pomeranians and Chihuahuas were significantly over\u2010represented, but correlations between inflammatory patterns of panniculitis and other histological and clinical factors were not identified. Based on the information available in medical records, 32 dogs (82.1%) had no concurrent systemic diseases identified. Four dogs had concurrent polyarthritis, which may be related to<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>through unknown mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\/Clinical Importance<\/jats:title><jats:p>This study identified several novel breed predilections for<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>; it failed to find any clear correlations with associated systemic diseases other than polyarthritis. The histological inflammatory pattern of<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>does not predict therapeutic outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12247","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T08:24:14Z","timestamp":1439886254000},"page":"451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Canine sterile nodular panniculitis: a retrospective study of 39 dogs"],"prefix":"10.1111","volume":"26","author":[{"given":"Caitlin L.","family":"Contreary","sequence":"first","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Outerbridge","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena K.","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Microbiology and Immunology School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip H.","family":"Kass","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"701","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.69.915"},{"key":"e_1_2_5_4_1","first-page":"551","article-title":"Panniculitis in dogs and cats: a retrospective analysis of 78 cases","volume":"24","author":"Scott DW","year":"1988","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00957.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0449.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2460\/javma.1982.180.04.422","article-title":"Disseminated necrotizing panniculitis and pancreatic nodular hyperplasia in a dog","volume":"180","author":"Moreau PM","year":"1982","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00162.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1994.tb03913.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45-4-475"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2003.tb00100.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.2460\/javma.1996.209.09.1582","article-title":"Serum a1\u2010antitrypsin concentration in dogs with panniculitis","volume":"209","author":"Hughes D","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2003.tb00104.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2001.00215.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00436.x"},{"key":"e_1_2_5_16_1","first-page":"152","article-title":"Nodular panniculitis in a female Toy Poodle","volume":"24","author":"Post K","year":"1983","journal-title":"Can Vet J"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12129"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T01:19:46Z","timestamp":1748567986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/vde.12247"],"URL":"https:\/\/doi.org\/10.1111\/vde.12247","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]},"assertion":[{"value":"2015-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}