{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:19:44Z","timestamp":1761059984309},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MSD Animal Health"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fluralaner is an isoxazoline systemic insecticide and acaricide that provides persistent flea\u2010killing activity on dogs for 12\u00a0weeks. European and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> field studies have shown that fluralaner treatment alleviates the signs of flea allergy dermatitis (<jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content>) in client\u2010owned dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objective<\/jats:title><jats:p>To assess the clinical response in <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> affected dogs over the 12\u2010week period following a single oral fluralaner treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty client\u2010owned dogs were diagnosed with <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> on the basis of compatible clinical signs and a positive response in flea antigen tests, using intradermal and or serological methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open\u2010label small\u2010scale study with all dogs receiving a single oral fluralaner treatment. All enrolled dogs were diagnosed with <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> and then clinically monitored at 4\u2010week intervals for 12\u00a0weeks. Twenty dogs completed the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All dogs were flea\u2010free at all post\u2010treatment assessments except for one dog that had a single flea at the first post\u2010enrollment assessment at 4\u00a0weeks. At the 4\u2010week post\u2010treatment assessment active <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> signs had resolved in all dogs; at 8\u00a0weeks post\u2010treatment, two dogs showed mild signs. All clinical signs of <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> had resolved at the final assessment of 12\u00a0weeks after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>A single administration of fluralaner alleviated or resolved signs associated with <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> in all treated dogs over the recommended 12\u2010week treatment period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12249","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T03:25:26Z","timestamp":1439522726000},"page":"417","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A small\u2010scale open\u2010label study of the treatment of canine flea allergy dermatitis with fluralaner"],"prefix":"10.1111","volume":"26","author":[{"given":"Petr","family":"Fisara","sequence":"first","affiliation":[{"name":"MSD Animal Health 26 Artisan Road Seven Hills 2147 NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Shipstone","sequence":"additional","affiliation":[{"name":"Dermatology for Animals 263 Appleby Road Stafford Heights 4053 NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"von Berky","sequence":"additional","affiliation":[{"name":"von Berky Veterinary Services 3 Hawthorne street Woody Point QLD 4019 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"von Berky","sequence":"additional","affiliation":[{"name":"von Berky Veterinary Services 3 Hawthorne street Woody Point QLD 4019 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-85"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-275"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-83"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-375"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12132"},{"key":"e_1_2_6_7_1","unstructured":"Australian code for the care and use of animals for scientific purposes 7th edition 2004 Australian Government. 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