{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:11:34Z","timestamp":1758633094992},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Epidermolysis bullosa acquisita (<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>) is a rare autoimmune subepidermal blistering disease of dogs and humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our objectives were to describe clinical phenotypes, histopathology and treatment outcomes of canine <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty dogs diagnosed with <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content> based on a subepidermal blister formation and collagen <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> autoreactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most dogs were young (median: 1.2\u2010year\u2010old) with a male\u2010to\u2010female ratio of 2.3:1. Nine of 20 dogs (45%) developed lesions before one year of age and 11 of 20 dogs (55%) were great danes. Tense vesicles and bullae (18 of 20; 90%) and deep erosions and ulcers (20 of 20; 100%) were the most common lesions and these affected predominantly the oral cavity (19 of 20; 95%), pinnae (16 of 20; 80%), axillae (15 of 20; 75%) and footpads (14 of 20; 70%). Histopathology identified neutrophilic perivascular dermatitis (17 of 17; 100%) without or with (12 of 17; 71%) eosinophils, which occasionally equalled (four cases) or outnumbered neutrophils (two cases). Subepidermal vesicles were either devoid of inflammation or contained neutrophils with or without eosinophils, fibrin and\/or haemorrhage. A complete remission of skin lesions was obtained in 14 dogs with a median time of 58 days. Glucocorticoids were used in these dogs either as a monotherapy (3 of 14; 21%) or in combination with other immunomodulating drugs (11 of 14; 79%). The median dose of prednisone was 3 mg\/kg\/day. The remaining six dogs were euthanized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Canine <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content> is a rare subepidermal blistering disease with an inflammatory phenotype and a predilection for young great danes and male dogs. The outcome of treatment appears more favourable than assumed previously.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12255","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T10:38:27Z","timestamp":1442313507000},"page":"441","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Canine epidermolysis bullosa acquisita: a retrospective study of 20 cases"],"prefix":"10.1111","volume":"26","author":[{"given":"Petra","family":"Bizikova","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith 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