{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:30:03Z","timestamp":1782563403540,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The high prevalence of antimicrobial resistance within otic pathogens has created a need for alternative therapies of otitis externa (OE). Evidence suggests that medical grade honey (<jats:styled-content style=\"fixed-case\">MGH<\/jats:styled-content>) may be effective against drug\u2010resistant pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The efficacy of a commercial <jats:styled-content style=\"fixed-case\">MGH<\/jats:styled-content> compound was assessed in an open clinical trial. We hypothesized that it would be an effective alternative to conventional treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Client\u2010owned dogs (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) with a confirmed diagnosis of infectious OE were enrolled in this pilot study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs were prescribed <jats:styled-content style=\"fixed-case\">MGH<\/jats:styled-content> (1\u00a0mL daily per ear) until cure was achieved or for a maximum of 21\u00a0d. Evaluation was based on weekly clinical scores, cytological progression and owner assessments of pruritus. Swab samples were submitted for culture and susceptibility testing. <jats:styled-content style=\"fixed-case\">MGH<\/jats:styled-content> was tested for biocidal activity against the bacterial isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Medical grade honey promoted rapid clinical progress, with 70% of dogs achieving clinical cure between days 7 and 14 and over 90% having resolved by Day 21. There was a decrease in clinical scores throughout the duration of the trial (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and owner\u2010assessed pruritus also decreased significantly (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). <jats:italic>In vitro<\/jats:italic> assays of the biocidal activity of <jats:styled-content style=\"fixed-case\">MGH<\/jats:styled-content> showed activity against all bacterial isolates, including meticillin\u2010resistant strains of <jats:italic>Staphylococcus pseudintermedius<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>) and other species of drug\u2010resistant bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical importance<\/jats:title><jats:p>Medical grade honey was successful in both clinical and laboratory settings, thus demonstrating its potential of becoming an alternative treatment for canine OE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12291","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T06:17:48Z","timestamp":1456813068000},"page":"93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of medical grade honey in the management of canine otitis externa \u2013 a pilot study"],"prefix":"10.1111","volume":"27","author":[{"given":"Emi","family":"Maruhashi","sequence":"first","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Avenida da Universidade T\u00e9cnica 1300\u2010477 Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta S\u00e3o","family":"Braz","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Avenida da Universidade T\u00e9cnica 1300\u2010477 Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telmo","family":"Nunes","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Avenida da Universidade T\u00e9cnica 1300\u2010477 Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constan\u00e7a","family":"Pomba","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Avenida da Universidade T\u00e9cnica 1300\u2010477 Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Belas","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Avenida da Universidade T\u00e9cnica 1300\u2010477 Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Henrique","family":"Duarte\u2010Correia","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Avenida da Universidade T\u00e9cnica 1300\u2010477 Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mafalda","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Avenida da Universidade T\u00e9cnica 1300\u2010477 Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(11)60016-6"},{"key":"e_1_2_6_3_1","first-page":"10","article-title":"History of Medicine","volume":"3","author":"Hajar R","year":"2002","journal-title":"Heart Views"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.07.003"},{"key":"e_1_2_6_5_1","first-page":"231","article-title":"Antibacterial honey: in\u2010vitro activity against clinical isolates of MRSA, VRE, and other multi\u2010resistant Gram\u2010negative organisms","volume":"19","author":"George NM","year":"2007","journal-title":"Wounds"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540902849383"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Honey based wound ointment for wound healing and skin disorders with animals","author":"Creemers T","year":"2006","journal-title":"Dier en Arts (Anim and Vet)"},{"key":"e_1_2_6_8_1","unstructured":"StobberinghEE VandersandenG.The anti\u2010bacterial activity of honey\u2010based ointment against antibiotic resistant Staph.\u00a0aureus and Ps.\u00a0aeruginosa (in\u2010vitro clinical isolates).L\u2010Mesitran\u00aeClinical Data File2010;4\u20138. 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