{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:51:33Z","timestamp":1763747493356,"version":"3.41.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The emergence of meticillin\u2010resistant<jats:italic>Staphylococcus pseudintermedius<\/jats:italic>(<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>) has become a significant animal health problem. Recent studies have indicated that previous antibacterial drug exposure is a factor in acquisition of meticillin\u2010resistant strains of staphylococci.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The purpose of this study was to identify factors associated with prior antimicrobial drug use and<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>pyoderma in dogs presented to a veterinary teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Dogs diagnosed with pyoderma associated with<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>(<jats:italic>n<\/jats:italic>= 53) or meticillin\u2010sensitive<jats:italic>S. pseudintermedius<\/jats:italic>(<jats:styled-content style=\"fixed-case\">MSSP<\/jats:styled-content>;<jats:italic>n<\/jats:italic>= 45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of dogs diagnosed with pyoderma associated with isolation of<jats:italic>S. pseudintermedius<\/jats:italic>between January 2006 and November 2012 were reviewed. All cases with a complete twelve month to 3 yr drug history prior to the diagnosis were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty two of 53 (98%)<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>cases and 42 of 45 (93%)<jats:styled-content style=\"fixed-case\">MSSP<\/jats:styled-content>cases had received at least one course of antibacterial drug prior to diagnosis. The total number of antibacterial drug prescriptions provided to pet owners and the variety of antibacterial drug classes represented were higher for cases with<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>than for cases with<jats:styled-content style=\"fixed-case\">MSSP<\/jats:styled-content>(<jats:italic>P<\/jats:italic>&lt; 0.0001 and<jats:italic>P<\/jats:italic>= 0.009, respectively). More cases with<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>(98%) received beta\u2010lactam drugs than those with<jats:styled-content style=\"fixed-case\">MSSP<\/jats:styled-content>(82%;<jats:italic>P<\/jats:italic>= 0.007) and the proportion of<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>cases that had received concurrent immunomodulatory therapy was higher (62% versus 42%;<jats:italic>P<\/jats:italic>= 0.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>These results suggest that the total number of antibacterial drug prescriptions, exposure to multiple drug classes (beta\u2010lactams in particular) and concurrent immunomodulatory therapy may be associated with increased risk for acquisition of<jats:styled-content style=\"fixed-case\">MRSP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12292","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:33:34Z","timestamp":1456374814000},"page":"72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prior antibacterial drug exposure in dogs with meticillin\u2010resistant<i>Staphylococcus pseudintermedius<\/i>(<scp>MRSP<\/scp>) pyoderma"],"prefix":"10.1111","volume":"27","author":[{"given":"Nao","family":"Hensel","sequence":"first","affiliation":[{"name":"Tierdermatologie Basel Emil Frey\u2010Strasse 127 CH\u20104142 M\u00fcnchenstein Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Zabel","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Georgia 501 D. 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