{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T20:27:55Z","timestamp":1768336075799,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"TAMU College of Veterinary Medicine"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Epidermolysis bullosa is a rare skin disease caused by defects in the basement membrane and\/or other dermoepidermal junction components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>We describe a series of spontaneous cases of dystrophic epidermolysis bullosa (DEB) in a colony of Sprague Dawley rats investigated with histopathology, transmission electron microscopy (<jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>) and inheritance pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Four, 4\u2010day\u2010old pups from a litter of Sprague Dawley rats developed blistering, haemorrhagic skin lesions and were euthanized. Age\u2010matched controls from the same litter were normal. Several months later two more litters presented with identical findings. All three litters had the same sire, suggesting a genetic component.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin from affected and control animals was evaluated histologically and with <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>. Unaffected sibling pairs from affected litters were bred in order to potentially reproduce the disease and determine the mode of inheritance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histologically, there was significant dermoepidermal clefting below the basement membrane with variable amounts of haemorrhage and cellular debris within the clefts. Ultrastructurally, clefting occurred below the basement membrane with an intact lamina densa and normal hemidesmosomes. Anchoring filaments were strikingly absent. Litters produced from phenotypically unaffected sibling pairs resulted in a total of four more litters with approximately a quarter of pups affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Based on the gross lesions, histopathological features and <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> determination of separation below the lamina densa and lack of normal anchoring fibrils, these cases are most consistent with <jats:styled-content style=\"fixed-case\">DEB<\/jats:styled-content>. This is the first report of naturally occurring, localized and reproducible recessive DEB in Sprague Dawley rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12293","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:25:05Z","timestamp":1456457105000},"page":"122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Congenital dystrophic epidermolysis bullosa (<scp>DEB<\/scp>) in Sprague Dawley rats: a case series"],"prefix":"10.1111","volume":"27","author":[{"given":"Kristin B.","family":"Eden","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine Texas A&amp;M University 422 Raymond Stotzer Parkway College Station TX 77845 USA"},{"name":"Department of Biomedical and Veterinary Sciences Virginia\u2010Maryland Regional College of Veterinary Medicine 245 Duck Pond Drive Blacksburg VA 24061 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