{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:44:54Z","timestamp":1791287094688,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Scabies infestation is one of the most pruritic dermatoses of dogs. It is often misdiagnosed and dogs are treated with immunomodulatory drugs (<jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>) to relieve pruritus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The primary goals of this study were to determine the impact of <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> on skin scraping results, pruritus level and extent of skin lesions, and to evaluate whether disease duration is associated with positive skin scrapings and contagion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Seventy nine dogs with a final diagnosis of scabies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion in this retrospective study required a positive skin scraping for scabies or a clinical response to an acaricidal treatment trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average pruritus score of dogs that received <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> (8.71) was significantly higher than those that did not (7.43; <jats:italic>P<\/jats:italic> = 0.03). However, there were no significant differences in either the rates of positive skin scrapings (79.6% versus 59.1%; <jats:italic>P<\/jats:italic> = 0.13) or the mean number of body sites affected (3.8 versus 3.4; <jats:italic>P<\/jats:italic> = 0.30) between dogs that received <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> and those that did not. Neither skin scraping status nor duration of clinical signs were correlated with a report of contagion within the household.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion\/Clinical importance<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> was associated with a significant increase in the pruritus level, but not with the mean number of lesional body sites. Dogs exposed to <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> had a 20.5% higher rate of positive skin scrapings. This difference could be clinically relevant and lack of statistical significance may indicate an underpowered study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12312","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T02:12:56Z","timestamp":1461550376000},"page":"160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can immunosuppressive therapy facilitate the diagnosis and affect the clinical signs of canine scabies? A retrospective study of 79 cases"],"prefix":"10.1111","volume":"27","author":[{"given":"Clarissa P.","family":"Souza","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota 1365 Gortner Ave St. Paul MN 55108 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M. 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