{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:23:23Z","timestamp":1770485003640,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T00:00:00Z","timestamp":1468800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014851","name":"Bayer Animal Health GmbH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014851","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mapracorat is a nonsteroidal Selective Glucocorticoid Receptor Agonist (<jats:styled-content style=\"fixed-case\">SEGRA<\/jats:styled-content>) that is presumed to have a better therapeutic index compared to classical glucocorticoids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and safety of mapracorat with classical glucocorticoids used for the treatment of allergic skin diseases in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Six laboratory beagles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effect of mapracorat on lipopolysaccharide\u2010induced <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 secretion from canine peripheral blood derived mononuclear cells (<jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>) was tested. <jats:italic>In vivo<\/jats:italic>, mapracorat was compared to triamcinolone acetonide using a skin inflammation model. Skin fold thickness was determined after daily administration of mapracorat and triamcinolone acetonide over 14 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mapracorat concentration dependently inhibited <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 secretion from activated canine <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content> with a half maximal inhibitory concentration (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub>) value of approximately 0.2 nmol\/L. Intradermal injection of compound 48\/80 (50 \u03bcg in 50 \u03bcL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre\u2010treatment with mapracorat (0.1%) and triamcinolone acetonide (0.015%) led to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. However, once daily topical administration of triamcinolone acetonide significantly reduced skin fold thickness from day 8 to 14, whereas no such reduction was observed for mapracorat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrate that mapracorat has comparable anti\u2010inflammatory efficacy to classical steroidal glucocorticoids under these experimental settings and maintenance of skin fold thickness indicates a better safety profile compared to triamcinolone acetonide at equipotent concentrations. This profile further suggests that <jats:styled-content style=\"fixed-case\">SEGRA<\/jats:styled-content>s show promise in the management of inflammatory and pruritic skin diseases in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12315","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T10:20:43Z","timestamp":1468837243000},"page":"46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The selective glucocorticoid receptor agonist mapracorat displays a favourable safety\u2013efficacy ratio for the topical treatment of inflammatory skin diseases in dogs"],"prefix":"10.1111","volume":"28","author":[{"given":"Wolfgang","family":"B\u00e4umer","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Institute of Pharmacology, Toxicology and Pharmacy University of Veterinary Medicine Hannover B\u00fcnteweg 17 Hannover 30559 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Rossbach","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Toxicology and Pharmacy University of Veterinary Medicine Hannover B\u00fcnteweg 17 Hannover 30559 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Bayer Animal Health GmbH Leverkusen 51373 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0515-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12186"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00782.x"},{"key":"e_1_2_5_5_1","first-page":"55","article-title":"Development and regression of dermal corticosteroid atrophy. 4. 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