{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:50:26Z","timestamp":1698238226142},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,3]],"date-time":"2016-07-03T00:00:00Z","timestamp":1467504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperaesthetic leucotrichia (<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>) rarely affects horses and causes painful lesions on the dorsum that result in leucotrichia. This may be a variant of erythema multiforme (<jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content>), but there are no studies investigating this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Describe the clinical and histological features of <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> and compare them to the histological features of <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of medical records from 1985 to 2015 identified 15 horses with <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>. Thirteen biopsies of <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> and five of <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content> were evaluated and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arabian horses and their crosses (\u03c7<jats:sup>2<\/jats:sup><jats:sub>(1)<\/jats:sub>\u00a0=\u00a08.56, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and American paint horses (\u03c7<jats:sup>2<\/jats:sup><jats:sub>(1)<\/jats:sub>\u00a0=\u00a06.64, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) were over represented. The onset of clinical signs was between April and September (14 of 15). The most common clinical signs were pain (15 of 15), leucotrichia (11 of 15), crusting (10 of 15) and alopecia (8 of 15) limited to darkly pigmented skin. The lesions recurred seasonally in 6 of 12 horses and unpredictably in 1 of 12 horse. The most common histological features were the presence of large stellate cells (13 of 13) and oedema (12 of 13) in the superficial dermis, perivascular to diffuse lymphocytic inflammation (13 of 13), pigmentary incontinence (12 of 13), apoptotic keratinocytes (9 of 13) and vesicle formation (8 of 13). Horses with <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) had significantly more acanthosis (<jats:italic>z<\/jats:italic>\u00a0=\u00a0\u22122.40, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.02) and lymphocytic exocytosis (<jats:italic>z<\/jats:italic>\u00a0=\u00a0\u22123.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.004), satellitosis (Fisher's exact <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and inflammation (<jats:italic>z<\/jats:italic>\u00a0=\u00a0\u22122.91, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.004). Horses with <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> had significantly more pigmentary incontinence (<jats:italic>z<\/jats:italic>\u00a0=\u00a02.13, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.04) and superficial dermal oedema (<jats:italic>z<\/jats:italic>\u00a0=\u00a02.56, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> affects primarily Arabian horses and American paint horses. It occurs mainly in summer and may recur. Histologically <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> shares features with <jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content>, but there are significant differences between them.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12327","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T02:57:55Z","timestamp":1467601075000},"page":"294","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A retrospective review of hyperaesthetic leucotrichia in horses in the <scp>USA<\/scp>"],"prefix":"10.1111","volume":"27","author":[{"given":"Elizabeth C.","family":"Goodale","sequence":"first","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Outerbridge","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela D.","family":"Everett","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena K.","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology &amp; Immunology School of Veterinary Medicine University of California Davis 1 Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30335-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00226.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0920-9.00012-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2005.tb00362.x"},{"key":"e_1_2_5_6_1","first-page":"647","volume-title":"Current Therapy in Equine Medicine","author":"Stannard A","year":"1987"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00222.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4102\/jsava.v62i3.1611","article-title":"Erythema multiforme in two horses","volume":"62","author":"Marshall C","year":"1991","journal-title":"J S Afr Vet Assoc"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2013.08.001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-009-0846-3"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-162571-1\/50010-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1985.tb02553.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80003-6"},{"key":"e_1_2_5_14_1","first-page":"431","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Roujeau J\u2010C","year":"2012"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074112"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277397"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70003-K"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02260.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.09.020"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000148"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.046"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00232.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4806846"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.01.021"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1997.02170470048009"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800106"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1302674"},{"key":"e_1_2_5_28_1","first-page":"2391","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Schmader KE","year":"2012"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(99)00042-6"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:12:46Z","timestamp":1695478366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,3]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/vde.12327"],"URL":"https:\/\/doi.org\/10.1111\/vde.12327","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,3]]},"assertion":[{"value":"2016-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}