{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T11:36:27Z","timestamp":1696937787529},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Background<\/jats:title>Sublingual immunotherapy (SLIT<\/jats:styled-content>) offers an alternative mode of allergen delivery to subcutaneous immunotherapy (SCIT<\/jats:styled-content>) with the aim of inducing immunological tolerance. Currently, there are no published reports regarding the efficacy or safety of SLIT<\/jats:styled-content> in horses.<\/jats:p><\/jats:sec>Hypothesis\/Objective<\/jats:title>To describe the first case of several adverse events occurring in a horse subsequent to the repeat administration of SLIT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Animal<\/jats:title>A seven\u2010year\u2010old, warmblood mare with a confirmed diagnosis of equine hypersensitivity dermatitis (EHD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods and results<\/jats:title>Immunotherapy was recommended for management of EHD<\/jats:styled-content>. Due to the temperament of the horse, the owner elected to proceed with SLIT<\/jats:styled-content>. Thirty six hours after commencing SLIT<\/jats:styled-content>, the mare developed scleral oedema, moderate dyspnoea and abdominal discomfort. SLIT<\/jats:styled-content> was withdrawn for 10 days and re instituted using a ten\u2010fold dilution of the original vaccine. Localized oedema and swelling of the tongue developed within 12 h of administration. At this juncture, SLIT<\/jats:styled-content> was withdrawn. The horse was rechallenged with the SLIT<\/jats:styled-content> allergen vehicle, 50% glycerine and no adverse reactions occurred. SCIT<\/jats:styled-content> was commenced using the same allergens and no adverse events occurred with repeated administration.<\/jats:p><\/jats:sec>Conclusions and clinical importance<\/jats:title>To the best of the authors' knowledge, this is the first reported case of adverse reactions developing subsequent to the administration of SLIT<\/jats:styled-content> for the management of EHD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12349","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T08:06:43Z","timestamp":1467101203000},"page":"439","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First report of angio\u2010oedema subsequent to the administration of allergen specific sublingual immunotherapy for the management of equine hypersensitivity dermatitis"],"prefix":"10.1111","volume":"27","author":[{"given":"Fiona 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