{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:58:34Z","timestamp":1770220714541,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coccidioidomycosis is a fungal disease caused by the dimorphic saprophytic fungus<jats:italic>Coccidioides immitis<\/jats:italic>or<jats:italic>C. posadasii<\/jats:italic>. Primary pulmonary infection can disseminate to cutaneous and subcutaneous tissues, or less commonly direct cutaneous inoculation may occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To characterize the historical, clinical, diagnostic and treatment findings in dogs and cats with cutaneous manifestation of coccidioidomycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty three dogs and seventeen cats diagnosed between 2009 and 2015 in Arizona, USA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of medical records from dogs and cats from an endemic area with a confirmed diagnosis via histopathology, cytology and\/or culture, and skin lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age of affected dogs ranged from 14 weeks to 13 years (median = 7 years), whereas cats ranged from 3 to 17 years (median = 9 years). Subcutaneous nodules were the most common lesions in both species. Lesions were distributed widely and not often found over sites of bone infection. In 75% of dogs and 54.5% of cats with cutaneous lesions there were clinical signs of systemic illness, supporting the diagnosis of cutaneous disseminated disease. Four dogs and four cats had localized lesions with no systemic illness, consistent with possible primary cutaneous infection. The most common mode of diagnosis was cytology identification in both species. Fluconazole was the most commonly prescribed antifungal drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Coccidioidomycosis is the most common mycosis of dogs and cats in endemic regions and cutaneous signs of the disease may be an initial presenting complaint. This study identified a variety of cutaneous manifestations of the disease in dogs and cats and should be recognized by clinicians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12356","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T02:53:31Z","timestamp":1468205611000},"page":"346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Retrospective analysis of cutaneous lesions in 23 canine and 17 feline cases of coccidioidomycosis seen in Arizona, USA (2009\u20132015)"],"prefix":"10.1111","volume":"27","author":[{"given":"Diana M.","family":"Sim\u00f5es","sequence":"first","affiliation":[{"name":"Dermatology for Animals 106 East Campbell Avenue Campbell CA 95008 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon M.","family":"Dial","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory The University of Arizona 2831 N. Freeway Road Tucson AZ 85705 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly S.","family":"Coyner","sequence":"additional","affiliation":[{"name":"Dermatology Clinic for Animals 5608 South Durango Street Tacoma WA 98409 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthea E.","family":"Schick","sequence":"additional","affiliation":[{"name":"Dermatology for Animals 22595 North Scottsdale Road #110 Scottsdale AZ 85255 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Thomas P.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Dermatology for Animals 86 West Juniper Avenue Gilbert AZ 85233 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1712-9_4"},{"key":"e_1_2_6_3_1","first-page":"634","volume-title":"Infectious diseases of the dog and cat","author":"Greene RT","year":"2012"},{"key":"e_1_2_6_4_1","first-page":"483","article-title":"Disseminated coccidioidomycosis of the dog","volume":"132","author":"Maddy KT","year":"1958","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15572536.2003.11833250"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myt005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2460\/javma.1979.174.05.504","article-title":"Primary cutaneous coccidioidomycosis in a dog and a cat","volume":"174","author":"Wolf AM","year":"1979","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-33-2-139"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0203.960305"},{"key":"e_1_2_6_10_1","first-page":"217","article-title":"Increase in reported Coccidioidomycosis \u2013 United States, 1998\u20102011","volume":"62","author":"Centers for Disease Control and Prevention","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.1846"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2005.07.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.3.247"},{"key":"e_1_2_6_14_1","first-page":"261","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb03277.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat, Clinical and histopathological diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.5326\/0440226"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.461"},{"key":"e_1_2_6_19_1","first-page":"50","volume-title":"Diseases of the nasal cavity and paranasal sinuses. Equine Respiratory Disease","author":"Rush B","year":"2008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.031"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2005.07.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2005.07.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12219"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12442280"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12356","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.12356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:29:52Z","timestamp":1748996992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,10]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/vde.12356"],"URL":"https:\/\/doi.org\/10.1111\/vde.12356","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,10]]},"assertion":[{"value":"2016-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}