{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:38:36Z","timestamp":1789882716772,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are few licensed options for the treatment of canine sarcoptic mange.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>\n                      Seventeen dogs with a diagnosis of\n                      <jats:italic>Sarcoptes scabiei<\/jats:italic>\n                      based on positive skin scrapings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By Day 14 post\u2010treatment, skin scrapings from all dogs were negative for mites. At the beginning of the study there was a negative correlation between body weight of the subject and pruritus [Pearson correlation coefficient (PCC) = \u22120.396,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007] and a positive correlation between pruritus and lesion severity (PCC 0.755,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0001). Significant decreases in lesion size and pruritus were observed within the first 14\u201321 days, respectively, and improvement in these parameters continued until the end of the study at Day 28.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fluralaner was effective in eliminating scabies mites within 14 days and significantly resolved the clinical signs associated with sarcoptic mange within 21 days after a single dose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.12363","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T06:12:42Z","timestamp":1470895962000},"page":"353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of fluralaner in 17 dogs with sarcoptic mange"],"prefix":"10.1111","volume":"27","author":[{"given":"Camilo","family":"Romero","sequence":"first","affiliation":[{"name":"Centro Universitario UAEM Amecameca Universidad Aut\u00f3noma del Estado de M\u00e9xico Carretera Amecameca\u2010Ayapango Km 2.5 Amecameca de Ju\u00e1rez CP 56900 Estado de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Heredia","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Agropecuarias y Recursos Naturales Universidad Aut\u00f3noma del Estado de M\u00e9xico kilometro 14.5 carretera Toluca\u2010Atlacomulco desviaci\u00f3n a Tlachalo El Cerrillo Piedras Blancas Toluca 50200 Estado de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Pineda","sequence":"additional","affiliation":[{"name":"Centro Universitario UAEM Amecameca Universidad Aut\u00f3noma del Estado de M\u00e9xico Carretera Amecameca\u2010Ayapango Km 2.5 Amecameca de Ju\u00e1rez CP 56900 Estado de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Licenciatura de Medicina Veterinaria y Zootecnia Centro Universitario UAEM Amecameca Universidad Aut\u00f3noma del Estado de M\u00e9xico Carretera Amecameca\u2010Ayapango Km 2.5 Amecameca de Ju\u00e1rez 56900 Estado de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n D.","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco Calzada del Hueso 1100 Coyoacan 04960 Mexico DF M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Porfirio","family":"Tr\u00e1pala","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Alhaurin R\u00edo Panuco No. 2424 Colonia M\u00e9xico Monterrey 64740 NL 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