{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:42:42Z","timestamp":1773063762102,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Rifampicin has received increased interest in veterinary dermatology because of its activity against multidrug\u2010resistant meticillin\u2010resistant staphylococci (<jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>). There is limited knowledge about the efficacy and safety of rifampicin in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objective<\/jats:title><jats:p>To provide information on response to treatment and adverse effects in dogs treated with rifampicin for multidrug\u2010resistant<jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>pyoderma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirty two dogs treated with rifampicin for rifampicin\u2010susceptible multidrug\u2010resistant<jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>pyoderma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of medical records, including alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) and alkaline phosphatase (<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>) serum activity levels and total bilirubin concentrations, obtained before and throughout the treatment, was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oral rifampicin as sole systemic antimicrobial therapy (median dose 5 mg\/kg twice daily) was effective in 71.88% of cases. Topical antimicrobials were used in most cases. Median duration of rifampicin treatment was five weeks for superficial pyoderma and four weeks for deep pyoderma. Gastrointestinal signs were reported in 15% of treated dogs. Statistically significant increases of<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>(<jats:italic>P<\/jats:italic>= 0.045) and<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>(<jats:italic>P<\/jats:italic>= 0.0002) values after 3\u20134 weeks of treatment was observed. The median increase was equal to 0.3 and \u00d71.5 the upper limit of the reference ranges for<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\/Clinical importance<\/jats:title><jats:p>Oral rifampicin combined with topical antimicrobials can be considered an effective therapeutic option for canine superficial and deep pyoderma caused by rifampicin\u2010susceptible multidrug\u2010resistant<jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>. Liver enzyme induction might be the most important cause of<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>increase associated with rifampicin therapy in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12404","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T02:07:30Z","timestamp":1482804450000},"page":"171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Rifampicin treatment of canine pyoderma due to multidrug\u2010resistant meticillin\u2010resistant staphylococci: a retrospective study of 32 cases"],"prefix":"10.1111","volume":"28","author":[{"given":"Michela","family":"De Lucia","sequence":"first","affiliation":[{"name":"Clinica Veterinaria Privata San Marco Via Sorio 114\/C 35141 Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Bardagi","sequence":"additional","affiliation":[{"name":"Department de Medicina i Cirurgia Animals Universitat Aut\u00f2noma de Barcelona 08193 Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Fabbri","sequence":"additional","affiliation":[{"name":"U.O. 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