{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:01:17Z","timestamp":1775602877315,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,29]],"date-time":"2017-01-29T00:00:00Z","timestamp":1485648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) is an uncommon cutaneous neoplasm in dogs. Treatment options are limited. Total skin electron therapy (<jats:styled-content style=\"fixed-case\">TSET<\/jats:styled-content>) has been suggested as a possible therapy for canine<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the use of<jats:styled-content style=\"fixed-case\">TSET<\/jats:styled-content>as palliative treatment for<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>in a dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An adult dog, previously diagnosed with nonepidermolytic ichthyosis, was presented with generalized erythroderma, alopecia and erosions. Histopathology revealed a densely cellular, well\u2010demarcated, unencapsulated infiltrate extending from the epidermis to the mid\u2010dermis compatible with<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. The infiltrate exhibited epitheliotropism multifocally for the epidermis, infundibula and adnexa. Due to a lack of response to chemotherapy,<jats:styled-content style=\"fixed-case\">TSET<\/jats:styled-content>was elected. Six megavoltage electrons were delivered using a 21<jats:styled-content style=\"fixed-case\">EX<\/jats:styled-content>Varian linear accelerator. A dose of 6 Gy was delivered to the skin surface and a 100 cm skin to surface distance was used for dog setup. The treatment time for the cranial half treatment was 3 h. The treatment was divided in two sessions (cranial and caudal halves of the body) 15 days apart. Clinical and histopathological complete remission was achieved and the dog was kept in remission with no additional treatments for 19 months before relapse and development of S\u00e9zary syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical significance<\/jats:title><jats:p>To the best of the authors\u2019 knowledge, this is the first case reporting the use of<jats:styled-content style=\"fixed-case\">TSET<\/jats:styled-content>for medically refractory canine<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>with post treatment follow\u2010up. This case suggests that the use of<jats:styled-content style=\"fixed-case\">TSET<\/jats:styled-content>may be an effective palliative treatment for canine<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12415","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T03:33:28Z","timestamp":1485747208000},"page":"246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Total skin electron therapy as treatment for epitheliotropic lymphoma in a dog"],"prefix":"10.1111","volume":"28","author":[{"given":"Domenico","family":"Santoro","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine University of Florida 2015 SW 16th Avenue Gainesville FL 32610 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndsay","family":"Kubicek","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine University of Florida 2015 SW 16th Avenue Gainesville FL 32610 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lu","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida 1275 Center Drive Gainesville FL 32611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Craft","sequence":"additional","affiliation":[{"name":"Department of Pathobiology College of Veterinary Medicine University of Florida 2015 SW 16th Avenue Gainesville FL 32610 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Conway","sequence":"additional","affiliation":[{"name":"Department of Pathobiology College of Veterinary Medicine University of Florida 2015 SW 16th Avenue Gainesville FL 32610 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01799.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2005.09.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00814.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2008.00176.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2003.01647.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.08.041"},{"key":"e_1_2_5_8_1","first-page":"1,124","article-title":"Evaluation of mycosis fungoides management by total skin electron beam therapy with \u201ctranslational technique\u201d","volume":"20","author":"Gamsiz H","year":"2015","journal-title":"J BUON"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","unstructured":"PrescottDM GordonJ.Total skin electron beam irradiation for generalized cutaneous lymphoma. 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