{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:14:05Z","timestamp":1762431245727},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,29]],"date-time":"2017-01-29T00:00:00Z","timestamp":1485648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hill's Pet Nutrition Italy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In areas endemic for leishmaniosis, discoid lupus erythematosus (<jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content>) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive\u2010ulcerative dermatitis in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objective<\/jats:title><jats:p>To compare histopathological and immunopathological features of canine nasal planum erosive\u2010ulcerative dermatitis with depigmentation due to <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content> or CanL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 14) or CanL (<jats:italic>n<\/jats:italic> = 6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sections of paraffin\u2010embedded samples, stained with haematoxylin and eosin were reviewed. Samples were examined using antibodies targeting T cells (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3), B cells (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20), macrophages (Mac387) and class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> major histocompatibility complex (<jats:styled-content style=\"fixed-case\">MHC II<\/jats:styled-content>). Histopathological and immunophenotypical findings were compared between <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content> and CanL cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lichenoid and interface dermatitis were observed in both <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content> and CanL cases. A nodular\u2010to\u2010diffuse, superficial and\/or deep dermatitis with macrophages, lymphocytes and plasma cells was present only in CanL samples. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20\u2010positive cells predominated over <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3\u2010 and Mac387\u2010positive cells in the two conditions. The percentage of dermal Mac387\u2010positive cells was higher in CanL compared to <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content> samples and the difference was statistically significant (<jats:italic>P<\/jats:italic> = 0.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\/Clinical importance<\/jats:title><jats:p>In this study, similar histopathological and immunopathological findings were observed in dogs with nasal planum lesions due to <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content> or CanL. Therefore, in areas endemic for leishmaniosis, the presence of the parasite should be investigated in canine nasal planum dermatitis showing clinical and histopathological features suggestive of <jats:styled-content style=\"fixed-case\">DLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12419","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T03:27:37Z","timestamp":1485746857000},"page":"200","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Michela","family":"De Lucia","sequence":"first","affiliation":[{"name":"Clinica Veterinaria Privata San Marco  Via Sorio 114\/C 35141 Padova Italy"},{"name":"Laboratorio d'Analisi Veterinarie San Marco Via Sorio 114\/C 35141 Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Mezzalira","sequence":"additional","affiliation":[{"name":"Laboratorio d'Analisi Veterinarie San Marco Via Sorio 114\/C 35141 Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Bardag\u00ed","sequence":"additional","affiliation":[{"name":"Department de Medicina i Cirurgia Animals Universitat Aut\u00f2noma de Barcelona 08193 Bellaterra, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolors M.","family":"Fondevila","sequence":"additional","affiliation":[{"name":"Department de Medicina i Cirurgia Animals Universitat Aut\u00f2noma de Barcelona 08193 Bellaterra, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Fabbri","sequence":"additional","affiliation":[{"name":"U.O. Qualit\u00e0 Ricerca Organizzativa e Innovazione, AUSL della Romagna Via Coriano 38 47924 Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Fondati","sequence":"additional","affiliation":[{"name":"Veterinaria Cetego Via M.C. 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