{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:43:54Z","timestamp":1774446234982,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,29]],"date-time":"2017-01-29T00:00:00Z","timestamp":1485648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cryptococcosis is an uncommon fungal infection in humans and mammals. Occasionally, cryptococcosis manifests as cutaneous lesions, either as an extension of nasal disease or as stand alone lesions unassociated with the nose. Histologically, these lesions are typically characterized by abundant organisms with mild granulomatous dermatitis. Herein, four feline cases of atypical cutaneous cryptococcal infections are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin punch biopsies from four client owned cats were submitted for histological evaluation between 2006 and 2015. Histological examination, including histochemical stains, was performed in all cases. Immunohistochemical stains and <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> were performed in three of four cases. Fungal culture was performed in two cases and transmission electron microscopy was performed in one case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Grossly, the cutaneous lesions were papular to nodular with occasional ulceration and were located predominantly on the trunk. Histological examination revealed severe granulomatous to pyogranulomatous and eosinophilic dermatitis with rare, capsule\u2010deficient yeasts. Immunohistochemistry, <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and fungal culture confirmed <jats:italic>Cryptococcus<\/jats:italic> spp. to be the aetiological agent in these cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>In cutaneous lesions, capsule\u2010deficient strains of <jats:italic>Cryptococcus<\/jats:italic> spp. may induce a severe inflammatory response with rare intralesional organisms that may not be readily identified on routine haematoxylin and eosin stained slides. Special stains with careful examination and ancillary tests (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, immunohistochemistry, fungal culture or antigen testing) should be performed when pyogranulomatous and eosinophilic dermatitis is encountered without an identifiable cause.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12423","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T03:37:24Z","timestamp":1485747444000},"page":"405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Atypical cutaneous cryptococcosis in four cats in the <scp>USA<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2680-6526","authenticated-orcid":false,"given":"Alexandra","family":"Myers","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine &amp; Biomedical Science Texas A&amp;M University College Station TX 77843 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-2702","authenticated-orcid":false,"given":"Courtney","family":"Meason\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine &amp; Biomedical Science Texas A&amp;M University College Station TX 77843 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Mansell","sequence":"additional","affiliation":[{"name":"Dermatopathology Specialty Service College of Veterinary Medicine &amp; Biomedical Science Texas A&amp;M University College Station TX 77843 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Krockenberger","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Sydney Sydney New South Wales 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanine","family":"Peters\u2010Kennedy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science College of Veterinary Medicine Cornell University Ithaca NY 14850 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Ross Payne","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine &amp; Biomedical Science Texas A&amp;M University College Station TX 77843 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Rodrigues Hoffmann","sequence":"additional","affiliation":[{"name":"Dermatopathology Specialty Service College of Veterinary Medicine &amp; Biomedical Science Texas A&amp;M University College Station TX 77843 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780310001624547"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2015.6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(08)01005-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.6.523.533"},{"key":"e_1_2_6_7_1","article-title":"Panfungal PCR for identification of fungal pathogens in formalin\u2010fixed animal tissues","author":"Smith CM","journal-title":"Vet Pathol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810369899"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-010-9328-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(09)01204-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.16.1.129-135.1977"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:36:27Z","timestamp":1696163787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,29]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/vde.12423"],"URL":"https:\/\/doi.org\/10.1111\/vde.12423","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,29]]},"assertion":[{"value":"2016-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}