{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:12:23Z","timestamp":1761581543299},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus foliaceus is a severe, autoimmune blistering skin disease, which is described in humans and some animal species. In small ruminants pemphigus foliaceus has rarely been described and, to the best of the authors\u2019 knowledge, little information is available about successful treatment in sheep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This case report describes a Berrichon du Cher ram with the presumed diagnosis of pemphigus foliaceus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ram was treated with methylprednisolone acetate 40\u00a0mg at a dosage of 2.5\u00a0mg\/kg in one subcuticular injection at four week intervals over a one\u00a0year period, with regular observation of clinical parameters. Four months after treatment was initiated the haematological parameters showed lymphopenia and leukopenia; some enzyme activities were substantially increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ram's dermatological condition improved to the point of complete healing of the affected skin. The ram was discharged in good condition. No adverse effects, except an elevation of some enzymes associated with liver function, were observed. At postmortem examination moderate fatty liver syndrome was the only abnormality found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>This case report demonstrated that long term therapy with methylprednisolone acetate in a sheep with pemphigus foliaceus did not have a negative effect on clinical parameters. Nevertheless, due to the extended statutory withdrawal period resulting from the regular administration of glucocorticoids, such a therapeutic option must be critically assessed in food producing animals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12442","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T17:38:18Z","timestamp":1491413898000},"page":"499","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of pemphigus foliaceus in a Berrichon du Cher ram with methylprednisolone acetate"],"prefix":"10.1111","volume":"28","author":[{"given":"Bianca","family":"Lambacher","sequence":"first","affiliation":[{"name":"University Clinic for Ruminants of the University of Veterinary Medicine Vienna Veterin\u00e4rplatz 1 1210 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Schoiswohl","sequence":"additional","affiliation":[{"name":"University Clinic for Ruminants of the University of Veterinary Medicine Vienna Veterin\u00e4rplatz 1 1210 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Brunthaler","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Forensic Veterinary Medicine of the University of Veterinary Medicine Vienna Veterin\u00e4rplatz 1 1210 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wittek","sequence":"additional","affiliation":[{"name":"University Clinic for Ruminants of the University of Veterinary Medicine Vienna Veterin\u00e4rplatz 1 1210 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhild","family":"Krametter\u2010Fr\u00f6tscher","sequence":"additional","affiliation":[{"name":"University Clinic for Ruminants of the University of Veterinary Medicine Vienna Veterin\u00e4rplatz 1 1210 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.114.19.479-a"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2460\/javma.1995.207.06.0761","article-title":"Use of corticosteroids and aurothioglucose in a pygmy goat with pemphigus foliaceus","volume":"207","author":"Valdez RA","year":"1995","journal-title":"J Am Vet Med Ass"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2002.00311.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.165.17.509"},{"key":"e_1_2_5_6_1","first-page":"1,345","article-title":"Pemphigus foliaceus in a juvenile Cashmere goat, and outcome after prednisolone and methylprednisolone therapy","volume":"52","author":"Janzen AM1","year":"2011","journal-title":"Can Vet J"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01489.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00540.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.05.005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051540"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470752487","volume-title":"Skin Disease of Dog and Cat. Clinical and histopathologic diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00360.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-001-0497-x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.123.13.335"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1953.tb13937.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1978.tb02271.x"},{"key":"e_1_2_5_17_1","first-page":"26","article-title":"Culicoides hypersensitivity in the horse: 15 cases in southwestern British Columbia","volume":"25","author":"Kleider N","year":"1984","journal-title":"Can Vet J"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"2,086","DOI":"10.2460\/javma.1991.198.12.2086","article-title":"Mosquito bite\u2010caused eosinophilic dermatitis in cats","volume":"198","author":"Mason KV","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.10.025"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(83)90031-4"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100103"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00599.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00459.x"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T12:40:30Z","timestamp":1719146430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/vde.12442"],"URL":"https:\/\/doi.org\/10.1111\/vde.12442","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]},"assertion":[{"value":"2017-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}