{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T11:51:10Z","timestamp":1759665070300,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) requires a multimodal therapy and there is a need for effective adjunctive interventions. TRPM8 agonists are known to alleviate pruritus by inducing cooling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of a novel <jats:styled-content style=\"fixed-case\">TRPM<\/jats:styled-content>8 agonist, 1\u2010diisopropylphosphorylheptane (Cryosim\u20101), in atopic dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Nine client owned dogs with moderate to severe pedal pruritus associated with nonseasonal <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, randomized, double\u2010blinded, intraindividual, placebo\u2010controlled study. A 2% Cryosim\u20101 or placebo\u2010vehicle cream was applied to each forepaw twice daily for seven days. The owner rated the pruritus manifestations once daily using a pedal Pruritus Visual Analog Scale (<jats:styled-content style=\"fixed-case\">PVAS<\/jats:styled-content>) and provided a Owner's Global Assessment of Treatment Efficacy (<jats:styled-content style=\"fixed-case\">OGATE<\/jats:styled-content>) at study end.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After seven days, the numbers of dogs with a pedal <jats:styled-content style=\"fixed-case\">PVAS<\/jats:styled-content> &lt;2.0 for Cryosim\u20101 and placebo were three and five of nine, respectively; likewise, <jats:styled-content style=\"fixed-case\">OGATE<\/jats:styled-content> scores of good\u2010to\u2010excellent were two and five of eight, respectively \u2013 these proportions were not significant between treatment groups (<jats:italic>P<\/jats:italic> = 0.32 and 0.16, respectively). Furthermore, there was no significant difference between Cryosim\u20101 and placebo in the median percentage change from baseline <jats:styled-content style=\"fixed-case\">PVAS<\/jats:styled-content> (47% versus 75%; <jats:italic>P<\/jats:italic> = 0.15) and in the number of dogs with a \u226550% or a \u226590% reduction from baseline pedal <jats:styled-content style=\"fixed-case\">PVAS<\/jats:styled-content> (four of nine versus five of nine, <jats:italic>P<\/jats:italic> = 0.50; two of nine versus two of nine, <jats:italic>P<\/jats:italic> = 0.72).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this pilot trial with a <jats:styled-content style=\"fixed-case\">TRPM<\/jats:styled-content>8 agonist in atopic dogs with pedal pruritus, the twice daily application of a 2% Cryosim\u20101 cream did not have an antipruritic effect superior to that of its vehicle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12486","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T03:52:57Z","timestamp":1506484377000},"page":"29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pilot evaluation of the antipruritic efficacy of a topical transient receptor potential melastatin subfamily 8 (<scp>TRPM<\/scp>8) agonist in dogs with atopic dermatitis and pedal pruritus"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-7718","authenticated-orcid":false,"given":"Chie","family":"Tamamoto\u2010Mochizuki","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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