{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:35:08Z","timestamp":1764102908906,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute radiation\u2010induced dermatitis (<jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>) is a common sequela of radiation therapy and carries the risk of secondary bacterial skin infection. No standard of care exists for managing canine <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content> and evidence\u2010based guidelines are lacking; however, prophylactic use of antibiotics is common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To evaluate the impact of prophylactic cefalexin on the prevalence and severity of bacterial infection in canine <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Seventeen dogs treated with definitive\u2010intent radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All dogs were treated with definitive\u2010intent radiation therapy (48\u201357.5 gray) targeted to the skin surface. Dogs were randomized to receive either prophylactic cefalexin (22 mg\/kg twice daily) beginning halfway through the prescribed radiotherapy course (cohort A) or to serve as controls (cohort B). Aerobic skin cultures and surface cytological evaluation were performed at first onset of moist desquamation and one week following completion of radiation therapy. Skin toxicity grading and owner quality of life (QoL) questionnaires were performed weekly. The rate of infection, multidrug resistance status, toxicity severity and QoL between cohorts were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Staphylococcus schleiferi<\/jats:italic> and <jats:italic>S. pseudintermedius<\/jats:italic> were the most frequent bacterial agents isolated in both cohorts. There was no significant difference in prevalence of bacterial infection or overall QoL between cohorts at either time point; however, multidrug\u2010resistant infections were significantly increased in cohort A versus cohort B. Clinician\u2010 and client\u2010perceived severity of toxicity was significantly greater and median duration of moist desquamation was significantly longer in cohort A than cohort B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Prophylactic use of cefalexin for management of canine <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content> is not recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12492","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:54:16Z","timestamp":1505746456000},"page":"37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of prophylactic cefalexin treatment on the development of bacterial infection in acute radiation\u2010induced dermatitis in dogs: a blinded randomized controlled prospective clinical trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-1320","authenticated-orcid":false,"given":"Michele A.","family":"Keyerleber","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Cummings School of Veterinary Medicine Tufts University 200 Westboro Road North Grafton MA 01536 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cummings School of Veterinary Medicine Tufts University 200 Westboro Road North Grafton MA 01536 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2007.00129.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00596.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2011.02.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6986-5_6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v17i4.493"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.08.005"},{"key":"e_1_2_7_8_1","unstructured":"Veterinary Radiation Therapy Oncology Group.Radiation Morbidity Scoring Scheme2017. Available athttp:\/\/www.acvr.org\/sites\/default\/files\/scoring_scheme.pdfAccessed Aug 09\/08\/2017."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.054"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radi.2008.08.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50004-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.COC.0000071418.12121.C2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2010.02170.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12444"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12118"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12138"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2010.00244.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku496"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr367"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.12.1450"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01046.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq241"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2010.09.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02193-06"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.12.018"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.7.2726-2729.2006"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:05:56Z","timestamp":1695474356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/vde.12492"],"URL":"https:\/\/doi.org\/10.1111\/vde.12492","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"type":"print","value":"0959-4493"},{"type":"electronic","value":"1365-3164"}],"subject":[],"published":{"date-parts":[[2017,9,18]]},"assertion":[{"value":"2017-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}