{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:23:35Z","timestamp":1770974615677,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Background<\/jats:title>C\u2010reactive protein (CRP<\/jats:styled-content>) is a major acute phase protein in dogs and may be an inflammatory marker of autoimmune diseases.<\/jats:p><\/jats:sec>Hypothesis\/Objectives<\/jats:title>To measure pre\u2010 and post\u2010treatment CRP<\/jats:styled-content> levels in dogs with superficial pyoderma (SP<\/jats:styled-content>) and pemphigus foliaceus (PF<\/jats:styled-content>) compared to normal dogs; to evaluate possible correlation between CRP<\/jats:styled-content> values, indirect immunofluorescence (IIF<\/jats:styled-content>), and pemphigus foliaceus extent and severity index (PEFESI<\/jats:styled-content>) scores.<\/jats:p><\/jats:sec>Animals<\/jats:title>Fifty nine dogs divided into three groups: Group I (control, n<\/jats:italic>\u00a0=\u00a031), Group II<\/jats:styled-content> (SP<\/jats:styled-content>, n<\/jats:italic>\u00a0=\u00a014) and Group III<\/jats:styled-content> (PF<\/jats:styled-content>, n<\/jats:italic>\u00a0=\u00a014).<\/jats:p><\/jats:sec>Methods<\/jats:title>CRP<\/jats:styled-content> levels were measured in Group I dogs. Skin biopsies of Groups II<\/jats:styled-content> and III<\/jats:styled-content> dogs were obtained for histopathological examination. In Group II<\/jats:styled-content> dogs, CRP<\/jats:styled-content> levels were measured at days 0, 15, 30 and 60. In Group III<\/jats:styled-content> dogs were evaluated by PEFESI<\/jats:styled-content>, IIF<\/jats:styled-content> and CRP<\/jats:styled-content> levels at days 0, 15, 30, 60 and 90.<\/jats:p><\/jats:sec>Results<\/jats:title>Group III<\/jats:styled-content> showed a higher median CRP<\/jats:styled-content> (37.4\u00a0mg\/mL) compared to the other groups (Group I, CRP<\/jats:styled-content> 2.9\u00a0mg\/mL, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001; Group II CRP<\/jats:styled-content> 3.8\u00a0mg\/mL, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.008). There was no significant difference in CRP<\/jats:styled-content> levels between groups I and II<\/jats:styled-content>. IIF<\/jats:styled-content> titres and CRP<\/jats:styled-content> levels decreased in most cases of PF<\/jats:styled-content> with clinical improvement. Dogs with CRP<\/jats:styled-content> >10.6\u00a0\u03bcg\/mL were 5.5 times more likely to have PF<\/jats:styled-content> than SP<\/jats:styled-content>. There was a strong positive correlation between CRP<\/jats:styled-content> values and PEFESI<\/jats:styled-content> and a weak positive correlation between CRP<\/jats:styled-content> values and IIF<\/jats:styled-content> titres.<\/jats:p><\/jats:sec>Conclusion and clinical importance<\/jats:title>CRP<\/jats:styled-content> levels are increased in dogs with PF<\/jats:styled-content> and exceed levels found in most dogs with SP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12510","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T03:52:42Z","timestamp":1511409162000},"page":"128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of C\u2010reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3358-4826","authenticated-orcid":false,"given":"Julia So","family":"Severo","sequence":"first","affiliation":[{"name":"Department of Clinical Science School of Veterinary Medicine University of S\u00e3o Paulo Av. 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