{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:11:46Z","timestamp":1781291506223,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Generalized demodicosis is a common disease in dogs and doramectin has been reported as a successful treatment. Different treatment protocols using doramectin have not been previously evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether oral administration of doramectin twice a week is more effective than administration by subcutaneous injection once a week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty nine privately owned dogs affected with generalized demodicosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs randomly received one of two treatments. Sixteen dogs were treated with 600 \u03bcg\/kg doramectin by subcutaneous injection once a week and 13 dogs received 600 \u03bcg\/kg doramectin by oral administration twice a week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of affected dogs was 2.8 and 2.6 years (<jats:italic>P<\/jats:italic>= 0.587) and the mean mite number detected at the initial evaluation was 201 and 287 (<jats:italic>P<\/jats:italic>= 0.04), respectively, for each group. The mean time to achieve negative skin scrapings was 13 and 12 weeks, respectively (<jats:italic>P<\/jats:italic>= 0.955). Adult\u2010onset demodicosis affected five of 16 and two of 13 dogs, respectively (<jats:italic>P<\/jats:italic>= 0.662). The success rate for treatment was 13 of 16 (81%) of dogs receiving subcutaneous injections once a week and 12 of 13 (92%) dogs receiving oral dosaging twice a week. (<jats:italic>P<\/jats:italic>= 0.691). Four dogs did not achieve disease remission. In the 12 month follow\u2010up period, one dog that had received the once a week protocol relapsed after eight weeks of treatment withdrawal. Adverse effects were not observed in any dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the results of this study, oral administration of doramectin twice a week does not achieve a more rapid resolution of canine generalized demodicosis than administration by subcutaneous injection once a week. The treatment success rate was the same for both protocols.\u2028<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12515","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T09:46:39Z","timestamp":1514540799000},"page":"104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Doramectin in the treatment of generalized demodicosis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-8633","authenticated-orcid":false,"given":"Alberto M.","family":"Cordero","sequence":"first","affiliation":[{"name":"Dermatologia Veterinaria Especializada Av. Ni\u00f1os Heroes 1665 Guadalajara Jalisco 44190 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Quek","sequence":"additional","affiliation":[{"name":"Mount Pleasant Animal Medical Centre 105 Clementi Street 12, #01\u201018\/20, Singapur 120105 Gelenggang 578187 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf S.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen Veterin\u00e4rstrasse 13 D\u201080539 M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01099.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12136"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1,308","DOI":"10.2460\/javma.1995.207.10.1308","article-title":"Ivermectin for treatment of generalized demodicosis in dogs","volume":"207","author":"Ristic Z","year":"2014","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00790.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1996.tb00233.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1992.tb00150.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1996.tb00248.x"},{"key":"e_1_2_5_9_1","first-page":"98","article-title":"Doramectin as a treatment for canine and feline demodicosis","volume":"32","author":"Johnstone IP","year":"2002","journal-title":"Aust Vet Pract"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.b4885"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12223"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.02.023"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T05:31:41Z","timestamp":1719725501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,29]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/vde.12515"],"URL":"https:\/\/doi.org\/10.1111\/vde.12515","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,29]]},"assertion":[{"value":"2017-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}