{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:55:45Z","timestamp":1785138945035,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF\u20102015R1D1A1A01060235"],"award-info":[{"award-number":["NRF\u20102015R1D1A1A01060235"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mupirocin is a topical antibacterial drug used for the treatment of staphylococcal infections, including meticillin\u2010resistant <jats:italic>Staphylococcus pseudintermedius<\/jats:italic> (MRSP). The recent emergence of resistance to mupirocin is a major concern in many countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study investigated the prevalence and genotype of mupirocin\u2010resistant <jats:italic>S.\u00a0pseudintermedius<\/jats:italic> isolated from pet dogs with pyoderma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Samples<\/jats:title><jats:p>A total of 110 clinical isolates of <jats:italic>S.\u00a0pseudintermedius<\/jats:italic> were collected from dogs with pyoderma (<jats:italic>n<\/jats:italic>\u00a0=\u00a0110) between July 2010 and September 2016. All animals were client\u2010owned dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Low\u2010 and high\u2010level mupirocin resistance were evaluated with both the broth microdilution and disk diffusion tests. Mupirocin resistance in <jats:italic>S.\u00a0pseudintermedius<\/jats:italic> isolates was confirmed by genetic analysis of the <jats:italic>ileS\u20102<\/jats:italic> and na\u00efve <jats:italic>ileS<\/jats:italic> genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MRSP and meticillin\u2010susceptible <jats:italic>S.\u00a0pseudintermedius<\/jats:italic> were detected in 69 and 41 dogs, respectively. One MRSP strain was highly resistant to mupirocin and contained the high\u2010level mupirocin resistance gene <jats:italic>ileS\u20102<\/jats:italic>. There were no low\u2010level mupirocin\u2010resistant isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical importance<\/jats:title><jats:p>Mupirocin is a useful topical antibacterial for MRSP, but a clinical MRSP isolate that had not previously been exposed to mupirocin exhibited the high\u2010level mupirocin resistance in phenotype and genotype. Therefore, continuous monitoring for mupirocin resistance is important in small animal practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12518","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T04:46:44Z","timestamp":1516769204000},"page":"95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Low prevalence of mupirocin resistance in <i>Staphylococcus pseudintermedius<\/i> isolates from canine pyoderma in Korea"],"prefix":"10.1111","volume":"29","author":[{"given":"Ji\u2010Hyung","family":"Park","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Dermatology College of Veterinary Medicine Seoul National University Seoul 08826 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Hun","family":"Kang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Dermatology College of Veterinary Medicine Seoul National 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