{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:28:48Z","timestamp":1759638528781,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Zoetis, Parsippany, NJ, USA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Various treatments are available for ear mite infestations in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The efficacy of sarolaner was evaluated against ear mite infestation caused by <jats:italic>Otodectes cynotis<\/jats:italic> in dogs and compared with topical moxidectin\/imidacloprid in a single\u2010masked, multi\u2010centre field study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Client\u2010owned dogs with <jats:italic>O. cynotis<\/jats:italic> infestation were treated monthly with oral sarolaner (<jats:italic>n<\/jats:italic> = 163) or topical moxidectin\/imidacloprid (<jats:italic>n<\/jats:italic> = 78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The presence of mites in the ear canals and the clinical signs associated with otoacariasis (including head shaking, pruritus\/ear scratching, trauma or alopecia of the pinnae, and erythema, ulceration and debris in the ear canals) was evaluated on days 0, 14 and 30, and, if applicable, on day 60. Dogs were considered cured of mite infestation following one (on day 0) or two (on days 0 and 30) monthly treatments, if no live mites were found in either ear. Non\u2010inferiority was evaluated at days 14 and 30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Parasitological cure was achieved in 76.4%, 90.5% and 93.3% of the sarolaner\u2010treated and in 53.9%, 63.5% and 66.7% of the moxidectin\/imidacloprid\u2010treated dogs on days 14, 30 and 60, respectively. At study completion, on day 60 at the latest, parasitological cure was achieved overall in 99.4% of sarolaner\u2010treated and 87.8% of moxidectin\/imidacloprid\u2010treated cases. The parasitological cure rate for sarolaner was non\u2010inferior to moxidectin\/imidacloprid at days 14 and 30. The clinical signs of otoacariasis improved throughout the study in both groups. There were no treatment\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A single oral administration of sarolaner was safe and highly effective in the treatment of <jats:italic>O. cynotis<\/jats:italic> infestation in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12521","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T04:06:39Z","timestamp":1517544399000},"page":"100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by <i>Otodectes cynotis<\/i>: a non\u2010inferiority study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-7678","authenticated-orcid":false,"given":"Csilla","family":"Becskei","sequence":"first","affiliation":[{"name":"Veterinary Medicine Research and Development Zoetis Mercuriusstraat 20 Zaventem 1930 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Cuppens","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research and Development Zoetis Mercuriusstraat 20 Zaventem 1930 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"Mahabir","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research and Development Zoetis 333 Portage St Kalamazoo MI 49007 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1,577","DOI":"10.1007\/s00436-009-1591-x","article-title":"Ectoparasites of dogs and cats in Albania","volume":"105","author":"Xhaxhiu D","year":"2009","journal-title":"Parasitol Res"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-016-5302-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2008000800005"},{"key":"e_1_2_6_5_1","first-page":"226","article-title":"Ectoparasite infestations of urban stray dogs in Greece and their zoonotic potential","volume":"33","author":"Lefkaditis MA","year":"2016","journal-title":"Tropical Biomedicine"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/9781119073680","volume-title":"Veterinary Parasitology","author":"Taylor M","year":"2015"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:APPA.0000021832.13640.ff"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00362.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00383-1"},{"key":"e_1_2_6_10_1","first-page":"304","volume-title":"Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-005-1449-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00300-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00299-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.vetpar.2015.02.022","article-title":"Clinical evaluation of the safety and efficacy of 10% imidacloprid + 2.5% moxidectin topical solution for the treatment of ear mite (Otodectes cynotis) infestations in dogs","volume":"210","author":"Arther RG","year":"2015","journal-title":"Vet Parasitol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.02.027"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s13071-016-1924-4","article-title":"Assessment of afoxolaner efficacy against Otodectes cynotis infestations of dogs","volume":"9","author":"Carithers D","year":"2016","journal-title":"Parasit Vectors"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13071-016-1954-y","article-title":"Efficacy of fluralaner against Otodectes cynotis infestations in dogs and cats","volume":"16","author":"Taenzler J","year":"2017","journal-title":"Parasit Vectors"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2017.02.029"},{"key":"e_1_2_6_19_1","unstructured":"EMEA.Guideline on good clinical practices. 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