{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:13Z","timestamp":1740126313656,"version":"3.37.3"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hearing loss (<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>) is classified as conductive when sound transmission is compromised in the ear canal or middle ear, or sensorineural when there is an abnormality of the receptor cells of the cochlea or auditory pathway. Hearing in dogs is evaluated using the brainstem auditory evoked response (<jats:styled-content style=\"fixed-case\">BAER<\/jats:styled-content>) test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>Our objective was to characterize <jats:styled-content style=\"fixed-case\">BAER<\/jats:styled-content> findings pre\u2010 and post\u2010ear flushing in four dogs with acute <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> following application of an ointment\u2010based otic medication containing betamethasone, clotrimazole and gentamicin in a mineral oil\u2010based system containing a plasticized hydrocarbon gel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Dogs, ranging from 9 to 11 years old, that had been treated with the otic medication for one to three weeks prior to hearing loss and on otoscopic examination had evidence of medication in the horizontal ear canals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs were anaesthetized for an ear flush to remove the medication from the ear canals. Hearing was assessed using <jats:styled-content style=\"fixed-case\">BAER<\/jats:styled-content> testing, measurements were initiated with 116 decibel peak equivalent sound pressure level (<jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content>pe<jats:styled-content style=\"fixed-case\">SPL<\/jats:styled-content>) click. Estimated threshold was defined as the lowest intensity in <jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content> in which wave V was still present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010ear flush the estimated threshold improved in both ears of all dogs (mean 22.3 <jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content>; range 13\u201341 <jats:styled-content style=\"fixed-case\">dB<\/jats:styled-content>), confirming conductive <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> due to the otic medication. All owners noted an improvement in their dog's hearing post\u2010ear flush, validating the <jats:styled-content style=\"fixed-case\">BAER<\/jats:styled-content> findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>These results emphasize the importance of an ear flush to remove otic medications in dogs that experience acute <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>, to determine if the <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> is conductive, and if so, to restore hearing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12542","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:59:32Z","timestamp":1523966372000},"page":"341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Conductive hearing loss in four dogs associated with the use of ointment\u2010based otic medications"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-7027","authenticated-orcid":false,"given":"Lynette K.","family":"Cole","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine The Ohio State University 1900 Coffey Rd Columbus OH 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi. J.","family":"Rajala\u2010Schultz","sequence":"additional","affiliation":[{"name":"Department of Production Animal Medicine Faculty of Veterinary Medicine University of Helsinki Paroninkuja 20 04920 Saarentaus Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-704X","authenticated-orcid":false,"given":"Gwendolen","family":"Lorch","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine The Ohio State University 1900 Coffey Rd Columbus OH 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb03490.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50090-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.08.012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.2177"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.009"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(89)50018-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50081-5"},{"key":"e_1_2_5_9_1","first-page":"205","article-title":"Alterations in the brain stem auditory evoked response threshold and latency intensity curve associated with conductive hearing loss in dogs","volume":"1","author":"Steiss JE","year":"1990","journal-title":"Prog Vet Neurol"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:36:01Z","timestamp":1695004561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/vde.12542"],"URL":"https:\/\/doi.org\/10.1111\/vde.12542","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"type":"print","value":"0959-4493"},{"type":"electronic","value":"1365-3164"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2018-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}