{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:15:28Z","timestamp":1768691728227,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In canine epitheliotropic cutaneous T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">ECTCL<\/jats:styled-content>), neoplastic cells cause skin lesions and potentially metastasize to lymph nodes, blood and other organs. Murine models are potentially valuable for elucidating the molecular mechanisms responsible for regulation of <jats:styled-content style=\"fixed-case\">ECTCL<\/jats:styled-content> cell migration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To describe a phenotype of mice xenografted with canine <jats:styled-content style=\"fixed-case\">ECTCL<\/jats:styled-content> cells (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>\u20101 cells).<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Four <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>17\u2010<jats:italic>Prkdc<\/jats:italic><jats:sup><jats:italic>scid<\/jats:italic><\/jats:sup>\/J (<jats:styled-content style=\"fixed-case\">NOD SCID<\/jats:styled-content>) mice were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>\u20101 cells were subcutaneously xenografted into <jats:styled-content style=\"fixed-case\">NOD SCID<\/jats:styled-content> mice. After four weeks, the development of tumour lesions in skin and other organs was investigated<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mice developed skin lesions with metastasis to the lymph nodes, spleen, lung, blood and liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Mice xenografted with <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>\u20101 cells may be useful for studying the pathogenesis of canine <jats:styled-content style=\"fixed-case\">ECTCL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12650","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T12:52:30Z","timestamp":1535633550000},"page":"517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phenotypic analysis of mice xenografted with canine epitheliotropic cutaneous 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