{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:14Z","timestamp":1740126314129,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"LETI"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Autosomal recessive congenital ichthyosis (<jats:styled-content style=\"fixed-case\">ARCI<\/jats:styled-content>) in golden retrievers is due to a <jats:italic><jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>1<\/jats:italic> gene mutation, which plays a role in epidermal lipid organization and metabolism. Topical therapies are used to reduce scaling; however, there are few published efficacy studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the efficacy of topical treatment based on gluconolactone, a polyhydroxy acid with known beneficial effects on stratum corneum structure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Sixteen golden retriever dogs with clinical signs of <jats:styled-content style=\"fixed-case\">ARCI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010confirmed <jats:italic><jats:styled-content style=\"fixed-case\">PNPLA<\/jats:styled-content>1<\/jats:italic> gene mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, multicentre, noncontrolled study. Dogs were treated with a shampoo and lotion containing gluconolactone and other hydroxyl acids. Treatments were administered initially twice weekly for two weeks, then once weekly for two weeks and finally once monthly. Examinations were performed prior to and at 14 and 30 days of treatment to assess scaling, presence of other skin lesions and pruritus. In two dogs, pre\u2010 and 30 day post\u2010treatment, skin biopsies were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The extent and size of the scales were reduced by 60% and 75% after 14 and 30 days of treatment, respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). In 20% of the dogs, scaling was no longer observed after the first 30 days of treatment. No other skin lesions or pruritus were observed in any dog. Post\u2010treatment biopsies showed normalization of the stratum corneum morphology and reduced hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical importance<\/jats:title><jats:p>The frequent use of a shampoo and lotion containing gluconolactone may be an effective measure to improve skin scaling in golden retrievers with <jats:styled-content style=\"fixed-case\">ARCI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12654","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T09:30:41Z","timestamp":1526981441000},"page":"323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Topical polyhydroxy acid treatment for autosomal recessive congenital ichthyosis in the golden retriever: a prospective pilot study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-7552","authenticated-orcid":false,"given":"Anna","family":"Puigdemont","sequence":"first","affiliation":[{"name":"Facultat de Veterin\u00e0ria Department of Pharmacology Therapeutics and Toxicology Edifici V Universitat Aut\u00f2noma de Barcelona 08913 Bellaterra, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-681X","authenticated-orcid":false,"given":"Nicla","family":"Furiani","sequence":"additional","affiliation":[{"name":"Studio di Dermatologia Veterinaria via Morandi 7\/C 06083 Ospedalicchio di Bastia Umbra, Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-8785","authenticated-orcid":false,"given":"Michela","family":"De Lucia","sequence":"additional","affiliation":[{"name":"San Marco Veterinary Clinic Via Sorio 114\/C 35141 Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-8331","authenticated-orcid":false,"given":"Isaac","family":"Carrasco","sequence":"additional","affiliation":[{"name":"CNR Veterinaris Riera Bast\u00e9 22 08830 Sant Boi de Llobregat, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-8358","authenticated-orcid":false,"given":"Laura","family":"Ordeix","sequence":"additional","affiliation":[{"name":"Facultat de Veterin\u00e0ria Department of Animal Medicine and Surgery Edifici V Universitat Aut\u00f2noma de Barcelona 08913 Bellaterra, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-0175","authenticated-orcid":false,"given":"Dolors","family":"Fondevila","sequence":"additional","affiliation":[{"name":"Facultat de Veterin\u00e0ria Department of Animal Medicine and Surgery Edifici V Universitat Aut\u00f2noma de Barcelona 08913 Bellaterra, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-463X","authenticated-orcid":false,"given":"Laura","family":"Rami\u00f3\u2010Lluch","sequence":"additional","affiliation":[{"name":"Laboratorios LETI Edifici Astrolabio Avinguda Cerdanyola 92 08172 Sant Cugat del Vall\u00e8s, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-6326","authenticated-orcid":false,"given":"Pilar","family":"Brazis","sequence":"additional","affiliation":[{"name":"Laboratorios LETI Edifici Astrolabio Avinguda Cerdanyola 92 08172 Sant Cugat del Vall\u00e8s, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45-2-174"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00667.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2009.00730.x"},{"key":"e_1_2_5_5_1","first-page":"507","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Fleckman P","year":"2012"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1056"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003848"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170708"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006651"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.19882069.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12323"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.249"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2340\/00015555674147","article-title":"Influence of repeated washing with soap and synthetic detergents on pH and resident flora of the skin of forehead and forearm. 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