{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:54:27Z","timestamp":1770220467954,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NCSU-CVM Foundation for Bartonella\/Vector Borne Diseases Research"},{"name":"IDEXX Laboratories"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Bartonella henselae,<\/jats:italic> a Gram\u2010negative, zoonotic, alpha\u2010proteobacteria has been previously implicated in association with cutaneous vasoproliferative lesions (bacillary angiomatosis), nodular panniculitis and multifocal erythema (erythema multiforme) in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Describe clinical, microbiological and histological lesions in a dog with ear margin vasculitis and <jats:italic>B.\u00a0henselae<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>A 12\u2010month\u2010old, specific pathogen\u2010free intact female beagle dog maintained in a vector\u2010free laboratory animal resource facility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p><jats:italic>Bartonella<\/jats:italic> and <jats:italic>Rickettsia<\/jats:italic> serological evaluation, <jats:italic>Bartonella<\/jats:italic> and <jats:italic>Rickettsia<\/jats:italic> PCR, <jats:italic>Bartonella<\/jats:italic> alpha\u2010proteobacteria growth medium (BAPGM) enrichment blood culture\/PCR, histopathological investigation and confocal immunohistochemical evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serological investigation (seroreversion) and PCR testing of aural tissue biopsies failed to support <jats:italic>Rickettsia rickettsii<\/jats:italic> as a cause of the aural vasculitis; however, <jats:italic>B.\u00a0henselae,<\/jats:italic> genotype San Antonio 2 DNA was amplified and sequenced from both ear tip margins and from normal\u2010appearing abdominal skin. Seroconversion to <jats:italic>B.\u00a0henselae<\/jats:italic> was documented retrospectively by IFA testing. <jats:italic>Bartonella henselae<\/jats:italic> organisms were visualized by confocal immunostaining within all three biopsies. Histopathology revealed small vessel necrotizing vasculitis and dermal necrosis. <jats:italic>Bartonella henselae s<\/jats:italic>eroreversion and complete resolution of skin lesions occurred in conjunction with administration of oral doxycycline and enrofloxacin for six weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Importance<\/jats:title><jats:p><jats:italic>Bartonella henselae<\/jats:italic> is an emerging zoonotic pathogen that has been associated with leucocytoclastic vasculitis in humans and may have had a contributing or causative role in the development of the cutaneous aural margin vasculitis in this beagle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12695","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T06:03:05Z","timestamp":1539583385000},"page":"537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>Bartonella henselae<\/i> in a dog with ear tip vasculitis"],"prefix":"10.1111","volume":"29","author":[{"given":"Brittany L.","family":"Southern","sequence":"first","affiliation":[{"name":"Laboratory Animal Resources College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Neupane","sequence":"additional","affiliation":[{"name":"Intracellular Pathogens Research Laboratory Comparative Medicine Institute College of Veterinary Medicine North Carolina State University 1050 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marna E.","family":"Ericson","sequence":"additional","affiliation":[{"name":"Dermatology Imaging Center Department of Dermatology University of Minnesota 2\u2010145 Jackson Hall, 321 Church St. S.E Minneapolis MN 55455 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie C.","family":"Dencklau","sequence":"additional","affiliation":[{"name":"Dermatology Imaging Center Department of Dermatology University of Minnesota 2\u2010145 Jackson Hall, 321 Church St. S.E Minneapolis MN 55455 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-2992","authenticated-orcid":false,"given":"Keith E.","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Intracellular Pathogens Research Laboratory Comparative Medicine Institute College of Veterinary Medicine North Carolina State University 1050 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel 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