{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:19:30Z","timestamp":1778055570138,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objective<\/jats:title><jats:p>To describe the effective treatment of pruritus associated with CM with lokivetmab in one dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<\/jats:title><jats:p>A 4\u2010year\u2010old, spayed female cross\u2010bred dog presented with severely pruritic, erythematous to pigmented macules and papules involving the ventral abdomen, interdigital skin, perivulval area and both pinnae; the pruritus had been unresponsive to treatment with antihistamines, prednisone and ciclosporin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Complete blood count and serum biochemistry, abdominal ultrasound, blood smear and skin cytological evaluation, <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, histopathological and immunohistochemical examination of skin biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Skin cytological evaluation revealed high numbers of uniform, heavily granulated mast cells; histopathological findings showed focal dermal proliferations of well\u2010differentiated, uniform mast cells consistent with a low\u2010grade mast cell tumour (MCT). Clinical staging revealed that the disease was confined to the skin. Mutations of <jats:italic>c\u2010kit<\/jats:italic> exon 8 and 11 were not detected. Treatment was initiated with anti\u2010canine\u2010interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201031 monoclonal antibody lokivetmab; antihistamines were continued. The dog's pruritus resolved within seven days and was maintained in remission over 15\u00a0months with once monthly lokivetmab injections; the skin lesions improved but did not resolve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical importance<\/jats:title><jats:p>Lokivetmab treatment was effective in resolving and maintaining pruritus remission in this dog with widespread cutaneous mast cell disease. Whether CM in dogs represent a separate entity that should be distinguished from a low\u2010grade MCT requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12702","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T04:14:04Z","timestamp":1543292044000},"page":"73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-2697","authenticated-orcid":false,"given":"Kristina","family":"Meichner","sequence":"first","affiliation":[{"name":"Department of Pathology College of Veterinary Medicine University of Georgia 501 D.W. Brooks Drive Athens GA 30602 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Kiupel","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigations and Michigan State University Veterinary Diagnostic Laboratory College of Veterinary Medicine Michigan State University 4125 Beaumont Road Lansing MI 48910 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanit","family":"Kasantikul","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigations and Michigan State University Veterinary Diagnostic Laboratory College of Veterinary Medicine Michigan State University 4125 Beaumont Road Lansing MI 48910 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Rakich","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Veterinary Medicine University of Georgia 501 D.W. Brooks Drive Athens GA 30602 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-4121","authenticated-orcid":false,"given":"Frane","family":"Banovic","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine University of Georgia 2200 College Station Road Athens GA 30602 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"54","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Horny HP","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589202900415"},{"key":"e_1_2_8_4_1","first-page":"508","article-title":"Urticaria pigmentosa\u2010like disease in the dog","volume":"29","author":"Jeromin AM.","year":"1993","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_8_5_1","first-page":"245","article-title":"Urticaria pigmentosa\u2010like disease in a dog","volume":"56","author":"Pariser MS","year":"2015","journal-title":"Can Vet J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2015-0038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00341.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2016.06.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-3-298"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812439215"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1364124"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12376"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.008"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:02:21Z","timestamp":1694692941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/vde.12702"],"URL":"https:\/\/doi.org\/10.1111\/vde.12702","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]},"assertion":[{"value":"2018-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}