{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:32:45Z","timestamp":1761060765707,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Background<\/jats:title>Cutaneous disseminated mycobacteriosis is rare in dogs. To the best of the authors\u2019 knowledge, the slowly growing mycobacterial species Mycobacterium nebraskense<\/jats:italic> has not been described before in this species.<\/jats:p><\/jats:sec>Objective<\/jats:title>Description of clinical features, laboratory analyses and treatment regimen of this unusual case.<\/jats:p><\/jats:sec>Animal<\/jats:title>A 9\u2010year\u2010old female\u2010spayed West Highland white terrier dog presented with progressive nodules and ulcerations on both sides of the thorax and the rostral aspect of the chest.<\/jats:p><\/jats:sec>Methods and materials<\/jats:title>Investigations involved histopathological examination of skin biopsies (including special stains for fungi, bacteria and mycobacteria), standard and mycobacterial culture (including susceptibility testing), 16S\/23S rRNA<\/jats:styled-content> sequencing and BLAST<\/jats:styled-content> similarity searching.<\/jats:p><\/jats:sec>Results<\/jats:title>Ziehl\u2013Neelsen staining of decontaminated biopsy material revealed acid\u2010fast bacteria morphologically consistent with mycobacteria. Treatment with clarithromycin and marbofloxacin achieved partial resolution. A change in the treatment regimen to pradofloxacin and azithromycin resulted in rapid deterioration of skin lesions. Final healing occurred with the addition of prednisolone at an anti\u2010inflammatory dose. The results of mycobacterial culture and susceptibility testing were received 10 and 12\u00a0months, respectively, after the first presentation of the dog. Therapy was stopped after 16\u00a0months without recurrence of skin lesions.<\/jats:p><\/jats:sec>Conclusions and clinical importance<\/jats:title>This case is noteworthy for the description of a new mycobacterial species contributing to disseminated panniculitis in a dog and for the difficulties experienced in the lengthy empirical treatment of slowly growing nontuberculous mycobacterial infections. The addition of prednisolone to induce complete healing raises the question of whether the mycobacterial infection was primary or whether it occurred secondarily to an ongoing sterile panniculitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12739","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T21:54:26Z","timestamp":1552946066000},"page":"262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mycobacterium nebraskense<\/i> infection in a dog in Switzerland with disseminated skin lesions"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9546-0768","authenticated-orcid":false,"given":"Katrin","family":"Timm","sequence":"first","affiliation":[{"name":"vetderm.ch Ennetseeklinik f\u00fcr Kleintiere AG Rothusstrasse 2 6331 H\u00fcnenberg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Welle","sequence":"additional","affiliation":[{"name":"Institute of Animal Pathology, Dermfocus Vetsuisse Faculty University of Bern L\u00e4nggass\u2010Strasse 122 3001 Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Friedel","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Bacteriology Vetsuisse Faculty University of Zurich Winterthurerstrasse 270 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00e8lle","family":"Gunn\u2010Moore","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies The Roslin Institute The University of Edinburgh Easter Bush Campus Midlothian EH25 9RG UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Peterhans","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Bacteriology Vetsuisse Faculty University of Zurich Winterthurerstrasse 270 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01104.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0795-3.00044-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5326\/0380217"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.63126-0"},{"key":"e_1_2_5_6_1","first-page":"205511691879268","article-title":"First report of nodular skin lesions caused by Mycobacterium nebraskense in a 9\u2010year\u2010old cat","volume":"4","author":"Niederh\u00e4user S","year":"2018","journal-title":"JFMS Open Rep"},{"key":"e_1_2_5_7_1","first-page":"9","volume-title":"Clinical Veterinary Microbiology","author":"Markey B","year":"2013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172474"},{"key":"e_1_2_5_9_1","first-page":"463","volume-title":"Advances in Veterinary Dermatology","author":"Carlotti DN","year":"1998"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.06.001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12247"},{"key":"e_1_2_5_12_1","first-page":"1,058","volume-title":"Infectious Disease of the Dog and Cat","author":"Stiles J","year":"2012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/9780470752487.ch12","volume-title":"Skin diseases of the dog and cat. 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