{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:55:01Z","timestamp":1777996501821,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcoptic mange in free\u2010ranging raccoon dogs (<jats:italic>Nyctereutes procyonoides<\/jats:italic>) caused by <jats:italic>Sarcoptes scabiei<\/jats:italic> is a widespread zoonotic disease that causes severe skin lesions with significant morbidity and mortality. Fluralaner is a member of the isoxazoline chemical class and is an acaricide and insecticide widely used in flea, tick and mite infections of dogs (<jats:italic>Canis lupus familiaris<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical efficacy of orally administered fluralaner in free\u2010ranging raccoon dogs naturally infected with sarcoptic mange.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Six raccoon dogs rescued at the Seoul Wildlife Center between November 2017 and April 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Raccoon dogs were treated with a single dose of a chewable fluralaner tablet. Clinical lesion scoring and superficial skin scraping were performed weekly for three weeks to assess treatment efficacy; the general health was assessed daily to monitor response and observe any adverse drug reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within seven days of treatment, a marked reduction in skin lesions was observed and mites were no longer present in skin scrapings. There was no evidence of re\u2010infestation and no additional drug administration was required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Although this was a nonrandomized, uncontrolled study of a small number of animals, it demonstrated that fluralaner may be suitable for treating sarcoptic mange in raccoon dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12741","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T07:49:55Z","timestamp":1553154595000},"page":"267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical efficacy of orally administered fluralaner for treatment of scabies in six free\u2010ranging raccoon dogs (<i>Nyctereutes procyonoides<\/i>)"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-2237","authenticated-orcid":false,"given":"Jae\u2010Eun","family":"Hyun","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Dermatology Research Institute for Veterinary Science College of Veterinary Medicine Seoul National University 1 Gwanak\u2010ro, Gwanak\u2010gu Seoul 08826 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Kyu","family":"Jang","sequence":"additional","affiliation":[{"name":"Seoul Wildlife Center 1 Gwanak\u2010ro, Gwanak\u2010gu Seoul 08826 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-0361","authenticated-orcid":false,"given":"Cheol\u2010Yong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Dermatology Research Institute for Veterinary Science College of Veterinary Medicine Seoul National University 1 Gwanak\u2010ro, Gwanak\u2010gu Seoul 08826 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-6291","authenticated-orcid":false,"given":"Seong\u2010Chan","family":"Yeon","sequence":"additional","affiliation":[{"name":"Seoul Wildlife Center 1 Gwanak\u2010ro, Gwanak\u2010gu Seoul 08826 Republic of Korea"},{"name":"Laboratory of Wildlife Medicine and the Research Institute for Veterinary Science College of Veterinary Medicine Seoul National University 1 Gwanak\u2010ro, Gwanak\u2010gu Seoul 08826 Republic of 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