{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:17:31Z","timestamp":1789168651339,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T00:00:00Z","timestamp":1555804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ischaemic dermatopathy represents a heterogenous and poorly\u2010characterized canine syndrome that is often refractory to conventional immunosuppression. Janus\u2010kinase inhibitors (JAKinibs) are used for the treatment of various human autoimmune diseases, including dermatomyositis. Oclacitinib is a generally well\u2010tolerated, veterinary\u2010approved, nonselective JAKinib that has therapeutic potential as an immunosuppressant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To describe four cases of treatment refractory juvenile\u2010onset ischaemic dermatopathy that rapidly and durably responded to oclacitinib administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Four mixed\u2010breed dogs, three 9\u2010month\u2010old male littermates and one 6\u2010month\u2010old female, were presented for generalized patchy alopecia, scarring and ulcerative dermatitis. Microscopic skin lesions were consistent with a severe ischaemic dermatopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>A complete remission of skin lesions could not be achieved in any dog with glucocorticoids alone, nor when these were combined with adjuvant immunosuppressants. Oclacitinib treatment was then initiated at the dosage of 0.4\u20100.7\u00a0mg\/kg twice daily, along with a tapering regimen of oral prednisolone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A full clinical remission was achieved within four weeks of starting this combination therapy, with prednisolone being stopped within eight weeks thereof. Remission was maintained in two dogs with lower doses or dosing frequencies of oclacitinib, whereas the two others required persistent twice daily administration of this JAKinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Oclacitinib was a useful immunosuppressive adjuvant to oral glucocorticoids for the treatment of refractory or severe cases of ischaemic dermatopathy in these four dogs. Such observation warrants further studies of the safety, efficacy and mechanism of action of oclacitinib as an immunosuppressant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12743","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T03:05:10Z","timestamp":1555902310000},"page":"201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The role of oclacitinib in the management of ischaemic dermatopathy in four dogs"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-7553","authenticated-orcid":false,"given":"Britt J.","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-2992","authenticated-orcid":false,"given":"Keith E.","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Comparative Medicine Institute NC State University Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-0034","authenticated-orcid":false,"given":"Thierry","family":"Olivry","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Comparative Medicine Institute NC State University Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/9780470752487.ch3","volume-title":"Skin Diseases of the Dog and Cat, Clinical and histopathological diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-5317-7.00006-0"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.09.008"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12128"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.10-0524"},{"key":"e_1_2_4_7_1","first-page":"371","article-title":"Juvenile\u2010onset ischaemic dermatopathy in two dogs treated with oclacitinib","volume":"29","author":"Pulsoni D","year":"2018","journal-title":"Vet Dermatol"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12101"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.06.006"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14064"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0866"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jisp.2017.10.003"},{"key":"e_1_2_4_13_1","first-page":"e119","article-title":"Jakinibs in inflammatory rheumatic diseases. 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