{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:27:43Z","timestamp":1769747263726,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Exfoliative dermatitis is a well\u2010recognized cutaneous paraneoplastic syndrome (<jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content>) associated with thymoma in cats, of which the clinical and histopathological presentation has been well\u2010characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe a novel clinical skin manifestation associated with thymoma in a cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<\/jats:title><jats:p>A 14\u2010year\u2010old neutered female domestic short hair cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Physical, abdominal ultrasonographic, thoracic radiographic, ultrasonographic and computed tomographic examinations, histopathological assessment of the skin and mediastinal mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cat was presented with noninflammatory alopecia, with a dorsal multifocal distribution. Examination of the alopecic areas using a dermascope indicated an apparent lack of follicular ostia. Histopathological assessment of alopecic areas confirmed follicular and epidermal atrophy<jats:bold>,<\/jats:bold> trichilemmal keratinization and mild orthokeratotic hyperkeratosis. Diagnostic imaging revealed a mediastinal mass, which was surgically removed. Histopathological and immunohistopathological examination of the mass was consistent with a thymoma, associated with multiloculated cyst formation and multifocal cholesterol granulomas. Following surgery, hair re\u2010growth was noted in the previously alopecic areas. The cat was euthanized 3.5\u00a0months later because of recurrent chylothorax suspected to be a postoperative complication. The alopecic lesions had improved markedly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Thymoma\u2010associated <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> might not always manifest as an exfoliative dermatitis and should be considered in the differential diagnosis of multifocal noninflammatory alopecia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12745","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T19:25:29Z","timestamp":1553541929000},"page":"342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A previously undescribed cutaneous paraneoplastic syndrome in a cat with thymoma"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-9459","authenticated-orcid":false,"given":"Quentin","family":"Fournier","sequence":"first","affiliation":[{"name":"Department of Small Animal Teaching Hospital The Royal (Dick) School of Veterinary Studies and The Roslin Institute University of Edinburgh, Easter Bush Edinburgh EH25 9RG Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spela","family":"Bavcar","sequence":"additional","affiliation":[{"name":"Department of Small Animal Teaching Hospital The Royal (Dick) School of Veterinary Studies and The Roslin Institute University of Edinburgh, Easter Bush Edinburgh EH25 9RG Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian W.","family":"Philbey","sequence":"additional","affiliation":[{"name":"Department of Easter Bush Pathology The Royal (Dick) School of Veterinary Studies and The Roslin Institute University of Edinburgh, Easter Bush Edinburgh EH25 9RG Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sionagh","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Easter Bush Pathology The Royal 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