{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:12Z","timestamp":1747188372291,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral neuroblastic tumours arising from primitive cells of the cranial and spinal ganglia and from sympathetic ganglion cells of the autonomic nervous system include, from most to least differentiated, ganglioneuroma, ganglioneuroblastoma and neuroblastoma. Canine ganglioneuroblastoma has been described in the mediastinum, nasal and oral cavities, as well as in the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical and histopathological findings, treatment and follow\u2010up of a primary cutaneous ganglioneuroblastoma affecting the footpad of a dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<\/jats:title><jats:p>An 8\u2010year\u2010old male German shepherd dog, referred for left forelimb lameness and licking of the footpad, showed thickening of the footpad of digit V with a central nodular lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Histopathological and immunohistochemical examination on a surgical skin biopsy specimen showed an infiltrative and highly cellular neoplasm in the deep dermis. The neoplasm was composed of large polyhedral cells with abundant cytoplasm containing Nissl substance that reacted strongly with neuron\u2010specific enolase and neuronal nuclei antigen, spindle cells with indistinct cell borders suggestive of Schwann cells, with a mild S\u2010100 and <jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content> immunoreactivity, and rare nests of neuroblasts. The owner agreed to digit amputation. Histologically, a neoplastic multinodular proliferation with morphological findings like those detected in the biopsy was observed, not extended to the surgical margins and without involvement of skeletal bone. No recurrence or metastasis was observed over a period of one year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>To the best of the authors\u2019 knowledge, this is the first report of a primary cutaneous ganglioneuroblastoma in a dog. Ganglioneuroblastoma should be included in the differential diagnoses of canine footpad neoplastic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12746","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T04:38:00Z","timestamp":1554525480000},"page":"346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Footpad peripheral ganglioneuroblastoma in a dog"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6358-7713","authenticated-orcid":false,"given":"Claudia","family":"Salvadori","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Veterinarie Universit\u00e0 di Pisa Viale delle Piagge 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cantile","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie Universit\u00e0 di Pisa Viale delle Piagge 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Massari","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Nervianese via Lampugnani 3 20014 Nerviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-5660","authenticated-orcid":false,"given":"Lavinia","family":"Chiti","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Nervianese via Lampugnani 3 20014 Nerviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Colombo","sequence":"additional","affiliation":[{"name":"Servizi Dermatologici Veterinari via Felice Musazzi 24 I\u201020025 Legnano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-4359","authenticated-orcid":false,"given":"Francesca","family":"Abramo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie Universit\u00e0 di Pisa Viale delle Piagge 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-5317-7.00004-7"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2013.11.211"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00612.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00780.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100616"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100219"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2003.09.002"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-3-282"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.08.014"},{"key":"e_1_2_4_11_1","first-page":"88","volume-title":"Tumors In Domestic Animals","author":"Goldschmidt MH","year":"2017"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.85115"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11773"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12746","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.12746","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T20:31:01Z","timestamp":1694291461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,5]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/vde.12746"],"URL":"https:\/\/doi.org\/10.1111\/vde.12746","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"type":"print","value":"0959-4493"},{"type":"electronic","value":"1365-3164"}],"subject":[],"published":{"date-parts":[[2019,4,5]]},"assertion":[{"value":"2019-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}