{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:45:16Z","timestamp":1790624716469,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Background<\/jats:title>The pathogenesis of canine atopic dermatitis (AD<\/jats:styled-content>) is complex. Dysregulation of the cutaneous immune system is considered an important regulator of the allergic response. Exploration of association of interleukin\u201017 (IL<\/jats:styled-content>\u201017), IL<\/jats:styled-content>\u201031, IgE and leukogram attributes with canine AD<\/jats:styled-content> could provide novel insights into its immunopathology.<\/jats:p><\/jats:sec>Hypothesis\/Objectives<\/jats:title>To investigate possible associations of IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u20103, IgE and leukogram attributes of canine AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Animals<\/jats:title>17 dogs diagnosed with AD<\/jats:styled-content> and six healthy dogs.<\/jats:p><\/jats:sec>Methods and materials<\/jats:title>Circulating concentrations of IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u201031 and total IgE from sera samples were determined using commercial canine\u2010specific quantitative immunoassay kits. Complete blood cell counts were analysed by an automated haematology analyser. Statistical differences between the two groups were determined using an unpaired t\u2010<\/jats:italic>test. The degree of relationship between the IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u201031, IgE, total leukocyte count (TLC<\/jats:styled-content>) values and clinical signs scores (Canine Atopic Dermatitis Lesion Index and pruritus Visual Analog Scale pVAS<\/jats:styled-content>) was determined by Pearson's r<\/jats:italic> correlation statistic.<\/jats:p><\/jats:sec>Results<\/jats:title>Dogs with AD<\/jats:styled-content> had significantly (P<\/jats:italic>\u00a0<\u00a00.0001) higher circulating concentrations of IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u201031 and total IgE compared with healthy dogs. Dogs with AD<\/jats:styled-content> also had significantly higher TLC<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.0002), absolute neutrophils (P<\/jats:italic>\u00a0<\u00a00.0001) and absolute eosinophils (P<\/jats:italic>\u00a0<\u00a00.0001) counts, and percentage of neutrophils (P<\/jats:italic>\u00a0<\u00a00.03) and eosinophils (P<\/jats:italic>\u00a0<\u00a00.0001) compared with healthy controls. A significant positive correlation (r<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.396; P<\/jats:italic>\u00a0<\u00a00.007) between the pVAS<\/jats:styled-content> and IL<\/jats:styled-content>\u201031 was observed in dogs with AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions and clinical importance<\/jats:title>Marked elevation in circulating IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u201031 and total IgE along with the abnormalities in leukogram may be associated with canine AD<\/jats:styled-content> and could be possible targets in the therapeutic management of canine AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12762","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T08:43:51Z","timestamp":1561020231000},"page":"383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Alterations in circulating concentrations of IL<\/scp>\u201017, IL<\/scp>\u201031 and total IgE in dogs with atopic dermatitis"],"prefix":"10.1111","volume":"30","author":[{"given":"Sujeet K.","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine College of Veterinary Science and Animal Husbandry UP Pandit Deen Dayal Upadhyaya Pashu\u2010Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU) Mathura 281 001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-4226","authenticated-orcid":false,"given":"Shanker K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Veterinary Science and Animal Husbandry UP Pandit Deen Dayal Upadhyaya Pashu\u2010Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU) Mathura 281 001 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