{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:40:27Z","timestamp":1791308427424,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Innovet Srl, Milano, Italy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Feline nonflea hypersensitivity dermatitis (<jats:styled-content style=\"fixed-case\">NFHD<\/jats:styled-content>) is a frequent cause of over\u2010grooming, scratching and skin lesions. Multimodal therapy often is necessary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To investigate the efficacy of ultramicronized palmitoylethanolamide (<jats:styled-content style=\"fixed-case\">PEA<\/jats:styled-content>\u2010um) in maintaining methylprednisolone\u2010induced remission in <jats:styled-content style=\"fixed-case\">NFHD<\/jats:styled-content> cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010seven <jats:styled-content style=\"fixed-case\">NFHD<\/jats:styled-content> cats with nonseasonal pruritus were enrolled originally, of which 25 completed all study requirements to be eligible for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Cats were randomly assigned to <jats:styled-content style=\"fixed-case\">PEA<\/jats:styled-content>\u2010um (15\u00a0mg\/kg per os, once daily; n\u00a0=\u00a029) or placebo (n\u00a0=\u00a028) while receiving a 28\u00a0day tapering methylprednisolone course. Cats responding favourably to methylprednisolone were then administered only <jats:styled-content style=\"fixed-case\">PEA<\/jats:styled-content>\u2010um (n\u00a0=\u00a021) or placebo (n\u00a0=\u00a023) for another eight weeks, followed by a four week long treatment\u2010free period. Cats were maintained in the study until relapse or study end, whichever came first. Primary outcome was time to relapse. Secondary outcomes were pruritus Visual Analog Scale (p<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">SCOR<\/jats:styled-content>ing Feline Allergic Dermatitis scale (<jats:styled-content style=\"fixed-case\">SCORFAD<\/jats:styled-content>) and owner Global Assessment Score (<jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean relapse time was 40.5\u00a0days (\u00b17.8 <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">PEA<\/jats:styled-content>\u2010um treated cats (n\u00a0=\u00a013) and 22.2\u00a0days (\u00b13.7 <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) for placebo (n\u00a0=\u00a012; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). On Day 28, the severity of pruritus was lower in the <jats:styled-content style=\"fixed-case\">PEA<\/jats:styled-content>\u2010um treated cats compared to placebo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). Mean worsening of pruritus at the final study day was lower in the <jats:styled-content style=\"fixed-case\">PEA<\/jats:styled-content>\u2010um group compared to placebo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), whereas <jats:styled-content style=\"fixed-case\">SCORFAD<\/jats:styled-content> was not different between groups. Mean owner <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content> at the final study day was better in the <jats:styled-content style=\"fixed-case\">PEA<\/jats:styled-content>\u2010um than the placebo\u2010treated group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical importance<\/jats:title><jats:p>Ultramicronized palmitoylethanolamide could represent an effective and safe option to delay relapse in <jats:styled-content style=\"fixed-case\">NFHD<\/jats:styled-content> cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12764","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T19:34:18Z","timestamp":1561491258000},"page":"387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea 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