{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:45:00Z","timestamp":1783370700504,"version":"3.54.6"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcoidosis is a granulomatous disease histologically characterized by naked granulomas in various mammals. Canine sarcoidosis is a rare disease which can cause nonpruritic papule, plaques and nodules on the trunk, neck, face and ear; it is usually treated with corticosteroids. To date, there are no published reports on alternatives to corticosteroids treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report a case of canine cutaneous sarcoidosis successfully treated with oral ciclosporin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<\/jats:title><jats:p>An 11\u2010year\u2010old beagle dog was presented with multiple pleomorphic plaques on the lateral thighs and dorsal trunk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Skin punch biopsy specimen were collected and analysed via routine histological examination and immunohistochemistry. After 14\u00a0weeks of oral ciclosporin treatment, repeat skin biopsy specimens were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathological examination revealed noncaseating epithelioid cell granuloma formation in the dermis. Dermal epithelioid cells were positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>18 and Iba1, but not for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 and E\u2010cadherin based on immunohistochemistry findings. Acid\u2010fast bacteria, fungi and <jats:italic>Leishmania<\/jats:italic> spp. were not detected by special stains, culture or polymerase chain reaction. An initial two week treatment with immunosuppressive doses of oral prednisolone and doxycycline was not effective. Skin lesions were almost in remission after 14\u00a0weeks of oral ciclosporin treatment without adverse events. Histologically, the dermal granulomatous lesions regressed and were replaced by fibrous tissues after ciclosporin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>This case report describes the clinical and histopathological presentation including immunohistochemistry and treatment outcome of a case of canine sarcoidosis Ciclosporin may be an effective alternative to corticosteroids for treating canine sarcoidosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12775","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T07:16:20Z","timestamp":1563779780000},"page":"438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and histopathological presentation and successful treatment with ciclosporin for canine sarcoidosis: a case report"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-4201","authenticated-orcid":false,"given":"Keita","family":"Iyori","sequence":"first","affiliation":[{"name":"Dermatological and Laboratory Service for Animals Vet Derm Tokyo 2\u201024\u20103 Kameido, Koto\u2010ku Tokyo 136\u20100071 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Shosha Animal Clinic 697\u20103 Shosha Himeji 671\u20102201 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Pathology The University of Tokyo 1\u20101\u20101 Yayoi Bunkyo\u2010ku 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine Division of Animal Life Science Graduate School Tokyo University of Agriculture and Technology 3\u20105\u20108 Saiwai\u2010cho Fuchu 183\u20108509 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinji","family":"Shirota","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology School of Veterinary Medicine Azabu University 1\u201017\u201071 Fuchinobe, Chuo\u2010ku Sagamihara 252\u20105201 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/235142"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00105805"},{"key":"e_1_2_4_5_1","first-page":"11","article-title":"Sterile sarcoidal granulomatous skin disease","volume":"15","author":"Scott 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