{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:39Z","timestamp":1787016159850,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Symmetrical lupoid onychomadesis (\n                      <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content>\n                      ) is a disease not infrequently seen in bearded collie dogs in Germany.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to compare historical and clinical data, as well as the mineral content of the hair and claws of bearded collies with\n                      <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content>\n                      with that of normal control dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty\u2010eight affected bearded collie dogs and 39 control dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and materials<\/jats:title>\n                    <jats:p>Owners completed an extensive questionnaire regarding upbringing, environmental conditions and diets. Claw specimens were obtained by claw trimming or gathering lost claws; hairs were obtained by plucking samples from several areas of the body; samples were converted to ash and evaluated in an atomic absorption spectrophotometer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinical signs in affected dogs eventually involved all claws on all paws. In twelve dogs recurrence of onychomadesis was observed. There was no relevant association between gender, housing, diet and health management, physical stress and the development of\n                      <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content>\n                      with exception of the age at which more intense exercise began. The most commonly used treatment combination was fatty acids, pentoxifylline and tetracycline; improvement occurred in 17 animals. Calcium, sodium and phosphorus concentrations were higher in the claws of affected dogs, whereas zinc concentrations were lower. The mineral content of hair samples of the affected dogs was not significantly different than controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and clinical importance<\/jats:title>\n                    <jats:p>Symmetrical lupoid onychomadesis in bearded collies is clinically similar to what has been described in other breeds with regard to clinical signs and response to treatment. Early strenuous activity may increase the risk for disease occurrence in this breed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.12779","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T03:04:34Z","timestamp":1563764674000},"page":"411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Canine symmetrical lupoid onychomadesis in bearded collies"],"prefix":"10.1111","volume":"30","author":[{"given":"Tanja","family":"Steimer","sequence":"first","affiliation":[{"name":"Small Animal Medicine Clinic Centre for Clinical Veterinary Medicine LMU Munich Veterinaerstrasse 13 80539 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bauer","sequence":"additional","affiliation":[{"name":"Statistical Consulting Unit StaBLab Department of Statistics LMU Munich Akademiestrasse 1 80799 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kienzle","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition and Dietetics Department of Veterinary Sciences LMU Munich Schoenleutnerstrasse 8 85764 Oberschlei\u00dfheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-5910","authenticated-orcid":false,"given":"Ralf S.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Small Animal Medicine Clinic Centre for Clinical Veterinary Medicine LMU Munich Veterinaerstrasse 13 80539 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012332"},{"key":"e_1_2_6_3_1","first-page":"1,448","article-title":"Disorders of the claw and clawbed in dogs","volume":"14","author":"Scott DW","year":"1992","journal-title":"Comp Cont Educ Pract Vet"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00174.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-31-3-194"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/0390139"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.1998.00094.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2001.tb01998.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-42-323"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00650.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-33-2-131"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-1-37"},{"key":"e_1_2_6_13_1","volume-title":"Manual of agricultural experimental and analytical methods (Handbuch der Landwirtschaftlichen Versuchs\u2010 und Untersuchungsmethodik) (VDLUFA\u2010Methodenbuch)","author":"VDLUFA","year":"2012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/978-3-642-34333-9","volume-title":"Regression: models, methods and applications","author":"Fahrmeir L","year":"2013"},{"key":"e_1_2_6_15_1","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm S","year":"1979","journal-title":"Scand J Statistics"},{"key":"e_1_2_6_16_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2018"},{"key":"e_1_2_6_17_1","unstructured":"HothornT BuehlmannP KneibTet\u00a0al.mboost: Model\u2010Based Boosting R package version 2018. 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