{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:44:08Z","timestamp":1784735048600,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Interdigital pyoderma is a common multifactorial, inflammatory disease of the canine interdigital skin. Lesions commonly become infected secondarily. In addition to management of the underlying cause, management of the chronic inflammatory changes in the interdigital skin created by secondary infection and by the release of keratin into deep tissues is required. Fluorescence biomodulation appears to modulate the inflammatory process in dermatological disorders and has shown promise in preliminary studies evaluating its use in superficial and deep pyoderma in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To evaluate the effect of a fluorescence biomodulation (<jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>) system used in conjunction with systemic antibiotic on clinical manifestations of canine interdigital pyoderma (CIP), compared to dogs treated with antibiotic alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirty\u2010six dogs diagnosed with CIP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Dogs were randomly allocated to treatment groups of either antibiotic alone (Group A) or antibiotic plus twice\u2010weekly <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content> application (Group B). Dogs were scored over a 12 week period on the basis of two measured parameters: a global lesion score composed of four different lesions types and neutrophil engulfing bacterial scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant decrease was seen by Week 3 in both measured parameters for Group B compared to Group A. The mean time\u2010to\u2010resolution of lesions was 4.3\u00a0weeks in Group B and 10.4\u00a0weeks in Group A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical importance<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content> system shows promise as an adjunct therapy to systemic antibiotic use in the management of CIP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12785","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T10:00:44Z","timestamp":1565690444000},"page":"371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Fluorescence biomodulation in the management of canine interdigital pyoderma cases: a prospective, single\u2010blinded, randomized and controlled clinical study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-0391","authenticated-orcid":false,"given":"Andrea","family":"Marchegiani","sequence":"first","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino via Circonvallazione 93\/95 I\u201062024 Matelica MC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Spaterna","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino via Circonvallazione 93\/95 I\u201062024 Matelica MC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cerquetella","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino via Circonvallazione 93\/95 I\u201062024 Matelica MC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-1876","authenticated-orcid":false,"given":"Adolfo M","family":"Tambella","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino via Circonvallazione 93\/95 I\u201062024 Matelica MC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Fruganti","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino via Circonvallazione 93\/95 I\u201062024 Matelica MC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-8684","authenticated-orcid":false,"given":"Susan","family":"Paterson","sequence":"additional","affiliation":[{"name":"Virtual Vet Derms Ltd., Lakeview 3 High Birkrigg Park Stainton Kendal, Cumbria LA8 0DY UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.06.028"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.05.027"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.09.012"},{"key":"e_1_2_5_5_1","first-page":"991","article-title":"Canine pododermatitis","volume":"57","author":"Bajwa J","year":"2016","journal-title":"Can Vet J"},{"key":"e_1_2_5_6_1","first-page":"106","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00662.x"},{"key":"e_1_2_5_8_1","first-page":"264","article-title":"Fusion podoplasty for the treatment of chronic fibrosing interdigital pyoderma in the dog","volume":"27","author":"Swaim SF","year":"1991","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5609"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2018.06.004"},{"key":"e_1_2_5_11_1","first-page":"36","article-title":"Light\u2010emitting diodes: a brief review and clinical experience","volume":"8","author":"Opel DR","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2016.882-887"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12144"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.11.744"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","unstructured":"ScapagniniG MarchegianiA RossiGet\u00a0al.Management of all three phases of wound healing through the induction of fluorescence biomodulation using fluorescence light energy. 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