{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:44:38Z","timestamp":1782168278547,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dermal arteritis of the nasal philtrum (<jats:styled-content style=\"fixed-case\">DANP<\/jats:styled-content>) is a cutaneous vascular condition that selectively targets large vessels of the nasal philtrum of dogs; little information is published about this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to report the signalment, clinical signs, treatment options and outcome of dogs with <jats:styled-content style=\"fixed-case\">DANP<\/jats:styled-content>, and to propose a rationale for the clinical diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010three dogs from four referral veterinary clinics from January 2002 to July 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Retrospective analysis of medical records of dogs with diagnosis of <jats:styled-content style=\"fixed-case\">DANP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age at disease onset was 5.3\u00a0years. Nineteen dogs were pure\u2010bred (11 different breeds) and four were mixed breed. Twenty\u2010three dogs had a clinical diagnosis of <jats:styled-content style=\"fixed-case\">DANP<\/jats:styled-content> and three of these had histopathological confirmation. Eight dogs had episodes of profuse arterial bleeding from the lesion, nine had minor bleeding and six no bleeding. Twenty dogs were managed medically with monotherapy or combined therapy of topical tacrolimus, prednisolone, doxycycline and niacinamide, and\/or pentoxifylline. Long\u2010term tacrolimus was prescribed for 15 cases, eight of those cases as sole therapy. Treatment was declined for three dogs and four dogs were lost to follow\u2010up. The lesion was satisfactorily controlled in 12 dogs and well\u2010controlled in four dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>The distinctive presentation of <jats:styled-content style=\"fixed-case\">DANP<\/jats:styled-content> substantiates the clinical diagnosis. Medical treatment seems to be effective in controlling <jats:styled-content style=\"fixed-case\">DANP<\/jats:styled-content> and tacrolimus used as sole or adjunctive therapy appears to manage the disease satisfactorily.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12790","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T09:27:57Z","timestamp":1567675677000},"page":"511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dermal arteritis of the nasal philtrum: a retrospective study of 23 dogs"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9455-7867","authenticated-orcid":false,"given":"Clarissa P.","family":"Souza","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine University of Illinois at Urbana\u2010Champaign Urbana IL 61802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M. F.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota 1365 Gortner Ave Saint Paul MN 55108 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-1597","authenticated-orcid":false,"given":"Sandra N.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota 1365 Gortner Ave Saint Paul MN 55108 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilene","family":"Bernardi de Souza","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques Facult\u00e9 Universit\u00e9 de Montr\u00e9al C.P. 5000, St Hyacinthe Quebec J2S 7C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2002.00309.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2008.00691.x"},{"key":"e_1_2_5_4_1","first-page":"483","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat, Clinical and histopathologic diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12502"},{"key":"e_1_2_5_7_1","first-page":"415","volume-title":"Advances in Veterinary Dermatology","author":"Campbell KL","year":"2010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/VMRR.S67182"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0301-732X2015000200020"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.24070\/bjvp.1983-0246.v10i2p47-51"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12790","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.12790","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T19:07:10Z","timestamp":1694200030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,5]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/vde.12790"],"URL":"https:\/\/doi.org\/10.1111\/vde.12790","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,5]]},"assertion":[{"value":"2019-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}