{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T12:32:01Z","timestamp":1713443521738},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UC Davis Center for Equine Health"},{"name":"University California, Davis"},{"name":"Fenway Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic progressive lymphoedema (CPL) is a disabling condition affecting various draft horse breeds, including Friesian horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The high incidence of CPL in Friesian horses suggests a genetic component and a predisposing phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>For the genomic study, 26 affected and 19 control horses were evaluated. Body measurements were taken from 28 affected and nine control Friesian horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Axiom\u00ae Equine Genotyping Array with a total of 307,474 single nucleotide polymorphism (SNPs) was used for the case\/control genome\u2010wide association study (GWAS). Height, weight and leg measurements (seven different body measurements) were obtained and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant associations were identified with the GWAS. There were significant differences (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in gaskin length measurements between CPL\u2010affected horses and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study suggests that the potential genetic contribution to CPL in Friesian horses is complex and may include other SNP\u2010associated factors. Significantly increased gaskin length of affected horses suggests a phenotype prone to developing CPL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12831","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T07:51:34Z","timestamp":1578383494000},"page":"234","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic progressive lymphoedema in Friesian horses: suggestive phenotype of affected horses and genome\u2010wide association study"],"prefix":"10.1111","volume":"31","author":[{"given":"Verena K.","family":"Affolter","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, Immunology School of Veterinary Medicine University California, Davis One Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Dalley","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction School of Veterinary Medicine University California, Davis One Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"Kass","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology School of Veterinary Medicine University California, Davis One Shields Avenue Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, Immunology School of Veterinary Medicine University California, Davis One Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Sonder","sequence":"additional","affiliation":[{"name":"UC Davis Center for Equine Health One Shields Avenue Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dannika L.","family":"Bannasch","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction School of Veterinary Medicine University California, Davis One Garrod Drive Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2013.08.007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/153968503768330238"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12087"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12256"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2014.11.004"},{"key":"e_1_2_5_7_1","first-page":"243","article-title":"Verrucous pastern dermatitis syndrome in heavy draught horses. 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