{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:16:40Z","timestamp":1789168600102,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperkeratotic erythema multiforme (HKEM) is a clinically distinct dermatosis and poorly characterized syndrome, comprised of hyperkeratotic plaques with variable symmetry and apoptosis similar to \u201cclassic\u201d erosive canine EM. Hyperkeratotic EM has a protracted clinical course and, although treatments with glucocorticoids, azathioprine and\/or ciclosporin have been tried, rates of remission are low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe successful treatment of HKEM in two dogs using oclacitinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>A 7\u2010year\u2010old, spayed Havanese dog (Case 1) and a 1\u2010year\u2010old, intact cryptorchid Dachshund dog (Case 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case characterization and clinical diagnoses were based on lesion character, surgical biopsy, cytological evaluation, culture, direct immunofluorescence (DIF) and expected responses to treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both cases exhibited multifocal, often symmetrical hyperkeratotic plaques with adherent scale. Histological findings revealed prominent epidermal hyperplasia, parakeratotic hyperkeratosis, lymphocytic dermatitis and transepidermal apoptosis with lymphocytic satellitosis. DIF revealed fine, patchy IgG, IgM and IgA basement membrane deposits (Case 2). Both dogs exhibited rapid improvement with oral oclacitinib (0.6\u20130.9\u00a0mg\/kg twice daily) with a complete remission of clinical signs observed in 12 and seven weeks in cases 1 and 2, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Importance<\/jats:title><jats:p>Oclacitinib could be considered as a fast\u2010acting and effective treatment option for HKEM in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12852","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T04:22:28Z","timestamp":1587356548000},"page":"330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Rapid response of hyperkeratotic erythema multiforme to oclacitinib in two dogs"],"prefix":"10.1111","volume":"31","author":[{"given":"Endya J.","family":"High","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-2992","authenticated-orcid":false,"given":"Keith E.","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research NC State University Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa B.","family":"Mamo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-7553","authenticated-orcid":false,"given":"Britt J.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-9144","authenticated-orcid":false,"given":"Ina","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-0528","authenticated-orcid":false,"given":"Petra","family":"Bizikova","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine NC State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research NC State University Raleigh NC 27606 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