{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:08:14Z","timestamp":1790100494949,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>R\u00e9sum\u00e9<\/jats:title><jats:sec><jats:title>Contexte<\/jats:title><jats:p>La TARC\/CCL17 (thymus and activation\u2010regulated chemokine) a \u00e9t\u00e9 impliqu\u00e9e dans la pathog\u00e9nie de la dermatite atopique canine (cAD). Les concentrations s\u00e9riques de TARC sont un biomarqueur fiable chez l\u2019homme atopique\u00a0; cependant, leur potentiel en tant que biomarqueur pour cAD n\u2019a pas \u00e9t\u00e9 \u00e9tudi\u00e9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypoth\u00e8ses\/Objectifs<\/jats:title><jats:p>Etudier si les concentrations s\u00e9riques de TARC corr\u00e8lent avec la s\u00e9v\u00e9rit\u00e9 de la maladie et les r\u00e9ponses th\u00e9rapeutiques pour cAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sujets<\/jats:title><jats:p>Trente \u2013 neuf chiens avec cAD et 42 chiens sains ont \u00e9t\u00e9 inclus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Mat\u00e9riels et m\u00e9thodes<\/jats:title><jats:p>Les concentrations s\u00e9riques en TARC chez les chiens avec cAD et les chiens sains ont \u00e9t\u00e9 mesur\u00e9es par ELISA avec anticorps anti\u2010TARC canin. La s\u00e9v\u00e9rit\u00e9 clinique de cAD a \u00e9t\u00e9 not\u00e9e par CADESI\u201004 (Canine Atopic Dermatitis Extent and Severity Index, 4th iteration). Les concentrations de TARC s\u00e9riques ont \u00e9t\u00e9 compar\u00e9es entre les chiens avec cAD et les chiens sains contr\u00f4les, et leur relation avec CADESI\u201004 a \u00e9t\u00e9 \u00e9tudi\u00e9e. Les concentrations s\u00e9riques de TARC ont aussi \u00e9t\u00e9 mesur\u00e9es chez 20 chiens avec cAD trait\u00e9s par prednisolone ou oclacitinib pendant quatre semaines.<\/jats:p><\/jats:sec><jats:sec><jats:title>R\u00e9sultats<\/jats:title><jats:p>Les concentrations s\u00e9riques de TARC \u00e9taient significativement plus \u00e9lev\u00e9es chez les chiens avec cAD que chez les chiens sains (<jats:italic>P<\/jats:italic> &lt; 0.001). Chez les chiens avec cAD, les concentrations s\u00e9riques de TARC corr\u00e9laient avec les scores de CADESI\u201004 (\u03c1 = 0.457, <jats:italic>P<\/jats:italic>&lt; 0.01). En outre, les concentrations s\u00e9riques de TARC diminuaient significativement chez les chiens trait\u00e9s avec att\u00e9nuation des signes cliniques (<jats:italic>P<\/jats:italic> &lt; 0.001). Les changements de concentrations s\u00e9riques de TARC avant et apr\u00e8s traitement corr\u00e9laient avec ceux des scores CADESI\u201004 (\u03c1 = 0.746, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions et importance clinique<\/jats:title><jats:p>Les concentrations s\u00e9riques de TARC ont le potentiel d\u2019\u00eatre un outil clinique et de recherche pour l\u2019\u00e9valuation objective de l\u2019intensit\u00e9 de la maladie et de la r\u00e9ponse th\u00e9rapeutique de la CAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12894","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T04:11:13Z","timestamp":1600402273000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Serum canine thymus and activation\u2010regulated chemokine (TARC\/CCL17) concentrations correlate with disease severity and therapeutic responses in 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