{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:07:23Z","timestamp":1789142843433,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>R\u00e9sum\u00e9<\/jats:title><jats:sec><jats:title>Contexte<\/jats:title><jats:p>Les sarco\u00efdes \u00e9quins sont la tumeur cutan\u00e9e la plus pr\u00e9valente chez le cheval dans le monde entier. Bien que plusieurs traitements soient disponibles, aucun n\u2019est totalement efficace et les r\u00e9cidives sont fr\u00e9quentes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectifs<\/jats:title><jats:p>D\u00e9terminer l\u2019efficacit\u00e9 et l\u2019innocuit\u00e9 de la cr\u00e8me imiquimod 5% et Sanguinaria canadensis + chloride de zinc dans le traitement de sarco\u00efdes \u00e9quins et \u00e9tudier les effets syst\u00e9miques potentiels sur les sarco\u00efdes distants non trait\u00e9s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sujets\/tumeurs<\/jats:title><jats:p>Vingt\u2010cinq chevaux de propri\u00e9taires avec un total de 164 tumeurs ont \u00e9t\u00e9 inclus dans l\u2019\u00e9tude. Cinquante\u2010sept tumeurs ont \u00e9t\u00e9 trait\u00e9es et 107 non trait\u00e9es.<\/jats:p><\/jats:sec><jats:sec><jats:title>Mat\u00e9riels et m\u00e9thodes<\/jats:title><jats:p>Des biopsies ont \u00e9t\u00e9 pr\u00e9lev\u00e9es, au moins une par cheval, les autres \u00e9taient diagnostiqu\u00e9es comme probablement des sarco\u00efdes \u00e0 partir de l\u2019aspect clinique. L\u2019imiquimod 5% (A) a \u00e9t\u00e9 appliqu\u00e9e trois fois par semaine, tandis que Sanguinaria canadensis + chloride de zinc (X) a \u00e9t\u00e9 appliqu\u00e9 tous les quatre jours apr\u00e8s une phase d\u2019initiation d\u2019une fois par jour pendant six jours. Le traitement a \u00e9t\u00e9 poursuivi jusqu\u2019\u00e0 r\u00e9mission clinique ou pendant 45 semaines maximum, avec une p\u00e9riode de suivi longue (34 mois en moyenne). Des biopsies des sarco\u00efdes ont \u00e9t\u00e9 renouvel\u00e9es apr\u00e8s la fin du traitement et en suivi si le propri\u00e9taire donnait son consentement.<\/jats:p><\/jats:sec><jats:sec><jats:title>R\u00e9sultats<\/jats:title><jats:p>Une r\u00e9mission compl\u00e8te a \u00e9t\u00e9 enregistr\u00e9e dans 84.4% (A) et 75.0% (X) des tumeurs. Une r\u00e9cidive a \u00e9t\u00e9 observ\u00e9e dans 7.3% (A) et 21.4% (X). Une r\u00e9mission spontan\u00e9e a \u00e9t\u00e9 observ\u00e9e dans 1,9% des tumeurs non trait\u00e9es. Aucun effet syst\u00e9mique ind\u00e9sirable sur les tumeurs non trait\u00e9es n\u2019a \u00e9t\u00e9 d\u00e9tect\u00e9. Au cours du traitement des degr\u00e9s variables d\u2019inflammation locale \u00e9taient fr\u00e9quents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion et importance clinique<\/jats:title><jats:p>Les deux traitements sont consid\u00e9r\u00e9s comme surs et efficaces. Les plus petites tumeurs r\u00e9pondaient plus favorablement au traitement. Le taux de r\u00e9cidive \u00e9tait faible et non observ\u00e9e au sein des biopsies r\u00e9p\u00e9t\u00e9es apr\u00e8s la fin du traitement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12900","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T10:04:06Z","timestamp":1601892246000},"page":"471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Topical treatment of equine sarcoids with imiquimod 5% cream or <i>Sanguinaria canadensis<\/i> and zinc chloride \u2013 an open prospective study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-2433","authenticated-orcid":false,"given":"Carina M.","family":"Pettersson","sequence":"first","affiliation":[{"name":"District and Official Veterinarian Swedish Board of Agriculture R\u00e5dmansgatan 55 Kristinehamn 681 34 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