{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:17:32Z","timestamp":1770833852784,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Sarcoptic mange is a parasitic disease causing severe pruritus, self\u2010induced skin lesions and secondary infections. In many cases, an antipruritic treatment is useful to decrease clinical signs of the disease. Oclacitinib is a synthetic janus kinase\u20101 (JAK1) inhibitor, that selectively inhibits cytokines involved in inflammation and pruritus. The aim of this retrospective study was to evaluate efficacy of oclacitinib in alleviating pruritus and inflammation in dogs affected by scabies. Forty\u2010four clinical records of dogs containing the words sarcoptes and oclacitinib were selected among dermatologic cases recorded within the last 5\u00a0years (2014\u20132019). Thirty\u2010one of 44 cases with confirmed sarcoptic mange infestation were included. All dogs were treated at day (D)0 with systemic antiparasitic drugs (e.g. moxidectin, sarolaner, afoxolaner) in association with oclacitinib at 0.5\u00a0mg\/kg by mouth every 12\u00a0hours for 14\u00a0days followed by oclacitinib administration every 24\u00a0hours for another 14\u00a0days. Visual Analogic Scale (VAS) was recorded at D0 and D30. Selected cases were 16 females and 15 males, median age was 4.5\u00a0years, majority were crossbred dogs. Mean VAS recorded at D0 was nine, and after onemonth decreased to three. Telephone follow up information, collected seven days after discharge, reported a significative decrease in pruritus within 24 hours. Our results suggest that the association of oclacitinib inhibition of JAK1 dependent cytokines (allergic and inflammatory associated IL2, IL4, IL6, IL13 and pruritogenic associated IL31) with conventional antiparasitic treatment, may be useful to provide quick relief from pruritus and decrease inflammation in dogs with sarcoptic mange.<\/jats:p>","DOI":"10.1111\/vde.12920","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T01:11:33Z","timestamp":1606180293000},"page":"505-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of oclacitinib as antipruritic drug during sarcoptic mange infestation treatment"],"prefix":"10.1111","volume":"31","author":[{"given":"L","family":"Cornegliani","sequence":"first","affiliation":[{"name":"Clinica Veterinaria Citt\u00e0 di Torino  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Guidi","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Citt\u00e0 di Torino  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Vercelli","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Citt\u00e0 di Torino  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,23]]},"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T04:29:03Z","timestamp":1693542543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,23]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/vde.12920"],"URL":"https:\/\/doi.org\/10.1111\/vde.12920","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,23]]},"assertion":[{"value":"2020-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}