{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:46Z","timestamp":1747188406584,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term follow\u2010up of oral fluralaner for canine demodicosis has not been demonstrated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A multicentre prospective open trial for the efficacy of oral fluralaner for the long\u2010term (&gt;12 month) management of canine demodicosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Client\u2010owned dogs diagnosed with demodicosis at nine veterinary clinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>A single fluralaner dose was administered orally. Although shampoo was allowed to treat secondary pyoderma, no other medication or shampoo was allowed, except for medication for possible underlying disorders. Each dog underwent a thorough parasitological and dermatological assessment monthly for three months and was followed up for &gt;12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six dogs were enrolled. Their ages ranged from three months to 16 years. The cases were nine juvenile and 17 adult onsets; and 18 generalised and eight localised forms. Fluralaner administration resulted in 100% eradication of mites and complete resolution of all skin lesions at three months. Seventeen dogs were excluded from the one year follow\u2010up evaluation as they had required a second dose of isoxazoline or died from causes unrelated to the fluralaner treatment. In the remaining nine cases, no relapse was observed in any of the dogs (six adult and three juvenile onsets; six generalised and three localised forms). Four dogs were monitored for over one year, one dog for over two years, and four dogs for three years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>The results indicated that a single dose of fluralaner could effectively deliver a long\u2010term cure when combined with managing underling conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12957","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T13:34:10Z","timestamp":1617888850000},"page":"368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term follow\u2010up of a single dose of fluralaner in nine dogs with demodicosis"],"prefix":"10.1111","volume":"32","author":[{"given":"Tomoya","family":"Hoshino","sequence":"first","affiliation":[{"name":"Dermatology Veterinary Specialists Emergency Centre 815 Ishigami Kawaguchi Saitama 333\u20100823 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Akita","sequence":"additional","affiliation":[{"name":"Akita Animal Hospital 165\u20106 Harihoshi Omitama Ibaraki 319\u20100133 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Sugeno","sequence":"additional","affiliation":[{"name":"Sugeno Animal Hospital 2\u20102 Ueki Toyano Fukushima Fukushima 960\u20108152 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Okamura","sequence":"additional","affiliation":[{"name":"Ohji Animal Hospital 3 Kuze Kuzenaka Minami Kyoto Kyoto 601\u20108213 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Machida","sequence":"additional","affiliation":[{"name":"AZ Animal Hospital 17\u20102 Kanai Oyama Itabashi Tokyo 173\u20100024 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-9710","authenticated-orcid":false,"given":"Masahiko","family":"Nagata","sequence":"additional","affiliation":[{"name":"Dermatology Veterinary Specialists Emergency Centre 815 Ishigami Kawaguchi Saitama 333\u20100823 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1638\/2017-0218.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12524"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2013.11.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12682"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.17-0274"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00344.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.01026.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.b4885"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.131"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1767-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04159-2"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.12957","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:49:41Z","timestamp":1693313381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/vde.12957"],"URL":"https:\/\/doi.org\/10.1111\/vde.12957","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"type":"print","value":"0959-4493"},{"type":"electronic","value":"1365-3164"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"2020-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}