{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:34:05Z","timestamp":1792712045088,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Otitis externa (OE) is a common disorder in dogs. Infection by the commensal yeast,<jats:italic>Malassezia pachydermatis<\/jats:italic>, may result in chronic disease that does not respond to standard primary care. Chronic infectious OE may be associated with otitis media (OM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objective<\/jats:title><jats:p>To report medical management, clinical outcomes and frequency of middle ear involvement, in dogs with<jats:italic>Malassezia<\/jats:italic>otitis unresponsive to primary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010nine dogs from one referral veterinary hospital from January 2007 to September 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Retrospective analysis of medical records of dogs referred with chronic otitis and treated for<jats:italic>Malassezia<\/jats:italic>otitis at a referral veterinary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic<jats:italic>Malassezia<\/jats:italic>OE was treated successfully in 91% of ears, in 87% of these cases with one ear flush intervention. Median time\u2010to\u2010resolution was 27\u00a0days after ear flush intervention. Neither duration of otitis, presence of neutrophils in aural discharge nor administration of oral itraconazole affected clinical outcome.<jats:italic>Malassezia<\/jats:italic>OM occurred concurrently in 17% of ears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>These findings assist clinicians and carers of affected dogs in decision\u2010making, by documenting that most cases of canine<jats:italic>Malassezia<\/jats:italic>otitis that have not resolved with standard primary care, can be treated successfully with a well\u2010staged and intense medical treatment plan.<jats:italic>Malassezia<\/jats:italic>OM should be suspected to occur concurrently in around a fifth of affected ears.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12995","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T03:03:10Z","timestamp":1625108590000},"page":"441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Malassezia<\/i>otitis unresponsive to primary care: outcome in 59 dogs"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-4084","authenticated-orcid":false,"given":"Johann M.","family":"Boone","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College Hawkshead Lane, North Mymms Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-9589","authenticated-orcid":false,"given":"Ross","family":"Bond","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College Hawkshead Lane, North Mymms Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-3729","authenticated-orcid":false,"given":"Anette","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College Hawkshead Lane, North Mymms Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan A.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College Hawkshead Lane, North Mymms Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-367X","authenticated-orcid":false,"given":"Anke","family":"Hendricks","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College Hawkshead Lane, North Mymms Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090501"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-1902-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50076-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.i412"},{"key":"e_1_2_6_6_1","volume-title":"Otitis externa in the dog. 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