{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:17:36Z","timestamp":1789168656803,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Canine atopic dermatitis (cAD) is a chronic disease characterised by hypersensitivity to environmental allergens. Oclacitinib maleate selectively inhibits pro\u2010inflammatory mediators associated with cAD. However, the impact of chronic oclacitinib use on immunocompetence requires further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Herein, we examined the potential immunomodulatory effects of prolonged oclacitinib treatment in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirteen privately owned dogs with cAD, treated with 0.4\u20130.6\u2009mg\/kg oclacitinib for 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Pruritus level was evaluated using a pruritus Visual Analog Scale (pVAS) and the canine atopic dermatitis extent and severity index, 4<jats:sup>th<\/jats:sup> iteration (CADESI IV). Peripheral blood samples were collected for routine laboratory assays and lymphocyte subtypes were analysed using flow cytometry. Antigen\u2010specific intracellular cytokine production from CD4+ and CD8+ T lymphocytes was analysed following <jats:italic>in\u2009vitro<\/jats:italic> stimulation by <jats:italic>Dermatophagoides farinae<\/jats:italic> antigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oclacitinib treatment significantly reduced pVAS and CADESI\u201004 scores, by 51% and 86.7%, respectively. Flow cytometric analysis revealed increased CD4+ and CD14+ lymphocyte populations. The cytokine profile at 360\u2009days after treatment initiation was similar to that before treatment and was not associated with clinical relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oclacitinib, when administered at the currently labelled dose for one year, is associated with a significant increase in circulating CD4+ T cells, but does not alter cytokine production from antigen\u2010stimulated T cells. The results reported do not support evidence for immunosuppression mediated by the mechanisms evaluated in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13037","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T06:59:50Z","timestamp":1636354790000},"page":"142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Immunomodulatory effect of long\u2010term oclacitinib maleate therapy in dogs with atopic dermatitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Guilherme","family":"De Caro Martins","sequence":"first","affiliation":[{"name":"CentroVet Veterinary Specialties 42 Raul Mendes St Belo Horizonte MG 30010\u2010030 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-9805","authenticated-orcid":false,"given":"Adriane Pimenta","family":"da Costa\u2010Val","sequence":"additional","affiliation":[{"name":"Clinics and Surgery Department Veterinary School Presidente Antonio Carlos Av, 6627 Belo Horizonte MG 31270\u2010901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Morcatti","family":"Coura","sequence":"additional","affiliation":[{"name":"Veterinary Department Bambu\u00ed\/Medeiros Road, Km 05 Faz Varginha MG 38900\u2010000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Matoso Lima","family":"Diamantino","sequence":"additional","affiliation":[{"name":"Clinics and Surgery Department Veterinary School Presidente Antonio Carlos Av, 6627 Belo Horizonte MG 31270\u2010901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Moller","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Clinics and Surgery Department Veterinary School Presidente Antonio Carlos Av, 6627 Belo Horizonte MG 31270\u2010901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otoni Alves","family":"de Oliveira Melo\u2010Junior","sequence":"additional","affiliation":[{"name":"Celular Interactions Biology Morfology Department Biological Sciences Institute Presidente Antonio Carlos Av, 6627 Belo Horizonte MG 31270\u2010901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo Cordeiro","family":"Giunchetti","sequence":"additional","affiliation":[{"name":"Celular Interactions Biology Morfology Department Biological Sciences Institute Presidente Antonio Carlos Av, 6627 Belo Horizonte MG 31270\u2010901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"da Silveira\u2010Lemos","sequence":"additional","affiliation":[{"name":"Universidade Jos\u00e9 Do Ros\u00e1rio Vellano 50 Indai\u00e1 St, UNIFENAS Belo Horizonte MG 31270\u2010020 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Martins","family":"Melo","sequence":"additional","affiliation":[{"name":"Clinics and Surgery Department Veterinary School Presidente Antonio Carlos Av, 6627 Belo Horizonte MG 31270\u2010901 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"61","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.08.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0515-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00889.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0514-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.f6662"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12194"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12101"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-12-253"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12088"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2018.10.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12698"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00758.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00728.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3242-6_6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12186"},{"key":"e_1_2_7_20_1","unstructured":"Zoetis.APOQUEL\u00ae (oclacitinib tablet): Fast\u2010acting and safe itch relief for dogs[Internet]. 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