{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:12:12Z","timestamp":1789215132022,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The antimicrobial effect of olanexidine was evaluated using minimal inhibitory concentration (MIC) towards <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>. Furthermore, its clinical efficacy in canine superficial pyoderma was assessed in a randomized, single\u2010blinded study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010eight client\u2010owned dogs with atopic dermatitis and superficial pyoderma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>The MIC of olanexidine was determined for <jats:italic>S. pseudintermedius<\/jats:italic> isolates (n=73) by serial dilution of 96\u2010well broth microdilution method. Regarding the clinical trial, all recruited dogs were randomized into two groups; one treated with 1.5% olanexidine spray once daily and the other with a 3% chlorhexidine shampoo once a week for 2 times, respectively. Clinical assessment was performed at days 0 and 14 according to the guidelines of the Japanese Society of Antimicrobials for Animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MIC values for methicillin\u2010resistant <jats:italic>S. pseudintermedius<\/jats:italic>\u2009(MRSP) and methicillin\u2010sensitive\u2009<jats:italic>S. pseudintermedius<\/jats:italic>\u2009(MSSP) were 0.23 \u03bcg\/ml and 0.24 \u03bcg\/ml (P =0.9), respectively. In clinical trial, olanexidine and chlorhexidine showed substantial improvement in clinical presentation compared to the baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Olanexidine showed comparable efficacy to chlorhexidine (P=0.73). Moreover, the MIC against\u2009<jats:italic>S. pseudintermedius<\/jats:italic>\u2009indicated high bactericidal activity, which was supported by the topical effectiveness of olanexidine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13038","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T06:36:49Z","timestamp":1637303809000},"page":"664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single\u2010blinded controlled trial"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-7268","authenticated-orcid":false,"given":"Yun\u2010Hsia","family":"Hsiao","sequence":"first","affiliation":[{"name":"Dermatological and Laboratory Service for Animals Vet Derm Tokyo 910 Shobusawa Fujisawa Kanagawa 252\u20100823 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