{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:37:40Z","timestamp":1790689060515,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oclacitinib administered at the licensed dose twice daily for two weeks and then once daily as required is recommended for the treatment of atopic dogs. In some cases, the once\u2010daily regimen is insufficient to control the clinical signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To provide preliminary safety and efficacy data on the prolonged twice\u2010daily administration of oclacitinib in atopic dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010three client\u2010owned atopic dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>The medical records of dogs with atopic dermatitis treated with oclacitinib twice daily for more than two weeks were reviewed retrospectively. Animal details, treatment dose and duration, concurrent diseases, adjunctive medications and possible adverse events were recorded. Treatment efficacy was assessed retrospectively and, when available, the selected blood parameters before and during the treatment were compared. Statistical analyses of the collected data were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median treatment duration was 113\u2009days. Excellent\u2010to\u2010good efficacy was observed in 38 dogs (72%), including 24 of 33 dogs that failed to respond to the once\u2010daily regimen. Eight dogs showed a poor response despite the addition of systemic glucocorticoids. Pyoderma, gastrointestinal signs and otitis externa were the most frequent adverse events recorded whilst on treatment. Blood tests performed in 35 dogs showed slightly decreased leucocyte, neutrophil, eosinophil and monocyte counts that remained within the reference ranges in most cases. Three dogs developed hypercholesterolemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>Prolonged twice\u2010daily administration of oclacitinib generally was well\u2010tolerated and was effective in most of the treated dogs. Regular clinical evaluation and blood tests are advisable for this treatment regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13053","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T11:38:51Z","timestamp":1641901131000},"page":"149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prolonged twice\u2010daily administration of oclacitinib for the control of canine atopic dermatitis: a retrospective study of 53 client\u2010owned atopic dogs"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-5163","authenticated-orcid":false,"given":"Daria","family":"Denti","sequence":"first","affiliation":[{"name":"Dermatology Unit, San Marco Veterinary Clinic and Laboratory Via dell\u2019Industria 3 Veggiano 35030 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Caldin","sequence":"additional","affiliation":[{"name":"Pathology Unit San Marco Veterinary Clinic and Laboratory Via dell\u2019Industria 3 Veggiano 35030 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Statistical Sciences University of Padova Via Cesare Battisti 241 Padova 35121 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-8785","authenticated-orcid":false,"given":"Michela","family":"De Lucia","sequence":"additional","affiliation":[{"name":"Dermatology Unit, San Marco Veterinary Clinic and Laboratory Via dell\u2019Industria 3 Veggiano 35030 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12101"},{"key":"e_1_2_6_3_1","unstructured":"European Medicines Agency website. 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